IgG4-related disease is a chronic fibroinflammatory disease with multiorgan involvement. Glucocorticoids and/or immunosuppressants as well as rituximab are both first-line treatments in remission induction therapy. However, relapse is common during the maintenance period, particularly in patients with re-elevation of serum IgG4 level. This study aims to evaluate whether adding mycophenolate mofetil (MMF) during the maintenance phase for such patients can reduce the risk of disease flare.

This study is a multicentre, randomised, double-blind, placebo-controlled study. A total of 108 eligible patients with re-elevation of serum IgG4 level during maintenance therapy will be included in this study and randomised in a 1:1 ratio to receive add-on MMF 0.5 g one time per day or placebo for 52 weeks. The primary outcome is the proportion of patients experiencing relapse at week 52. Secondary outcomes include time-to-relapse, changes in disease activity and serum IgG4 level, stratified relapse rate according to the elevation level of IgG4. Analyses will follow the intention-to-treat principle.

The study has been approved by the Ethics Committee of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences (approval no. K3231). Written informed consent will be obtained from all participants before enrolment. Findings will be disseminated through peer-reviewed journals and conference presentations.

NCT05974683.

Healthcare settings are high-risk environments for the transmission of respiratory viruses. Effective strategies to prevent hospital-acquired influenza, particularly post-exposure prophylaxis for close contacts (CCs), are urgently needed. This study aims to assess the effectiveness of baloxavir marboxil (baloxavir) and oseltamivir in preventing influenza virus infection among CCs who have been exposed to confirmed influenza cases and are unable to be immediately isolated in the hospital ward.

This multicentre, randomised, open-label, parallel-controlled trial involves hospitalised patients with laboratory-confirmed influenza (index patients) and their CCs. CCs will be randomised into three groups: baloxavir marboxil, oseltamivir or placebo. Baloxavir (40 mg or 80 mg for ≥80 kg) will be administered as a single dose on day 1, while oseltamivir (75 mg) will be given once a day for 5 days. CCs will be monitored for influenza-like symptoms, with respiratory samples collected for rapid antigen test or reverse-transcription PCR testing at baseline, day 5±1 and day 10±1 or earlier if symptoms develop. The primary outcome is the 5-day incidence of clinical influenza, defined as laboratory-confirmed infection with concurrent fever and at least one respiratory symptom. Secondary outcomes will include the 5-day incidence of laboratory-confirmed influenza, the 10-day incidence of clinical influenza and the percentage of CCs infected with resistance-associated treatment-emergent influenza variants.

The study has been approved by the Clinical Research Ethics Committee of China-Japan Friendship Hospital (2024-KY-401). The results of the study will be submitted for publication in a peer-reviewed journal with online accessibility. The full protocol, de-identified participant data and statistical code will be openly available in a public repository within 12 months after trial completion.

NCT06762587.

Music-based interventions are increasingly used as supportive, non-pharmacological approaches in clinical care, yet nursing roles are often described inconsistently and intervention terminology and reporting remain heterogeneous. This scoping review will map the available evidence on music-based interventions with an explicit nursing role, referred to collectively in this review as nurse-led music-based interventions, for patients or care recipients across clinical care settings, with attention to populations, nursing roles, intervention characteristics, reported outcomes and implementation issues.

The review will follow Joanna Briggs Institute (JBI) scoping review methodology and will be reported according to Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Preliminary searches of MEDLINE, CINAHL, Embase, Scopus, Web of Science Core Collection, PsycINFO, CNKI, Wanfang Data and VIP Information were conducted on 4 May 2026 solely to validate the database-specific search strategies; the formal search has not commenced. Formal searches of these databases and planned grey literature sources will be conducted from 1 to 7 September 2026, with an update search in February 2027 and completion anticipated in March 2027. Eligible sources will report an explicit and identifiable nursing role in a music-based intervention. Primary roles will be classified using prespecified responsibility-based definitions as nurse-led, nurse-managed, nurse-coordinated, nurse-delivered, nurse-facilitated or multidisciplinary with an explicit nursing role; all reported nursing activities and multidisciplinary involvement will also be retained. Two reviewers will independently undertake each stage of study selection and data charting, with adjudication when consensus cannot be reached. Findings will be presented through descriptive summaries, evidence mapping, tabular displays and narrative synthesis.

Ethical approval is not required because this review will use published and publicly accessible sources. Findings will be disseminated through peer-reviewed publication and conference presentations.

The protocol was registered on the Open Science Framework on 11 April 2026 (https://osf.io/c6ytn)

Accelerated population ageing has resulted in increasingly diverse and complex care needs among older people, posing a major challenge to healthcare systems worldwide. Nursing personnel represent a core workforce in the delivery of healthcare and nursing services for older people, and their geriatric nursing competence (GNC) is closely associated with the quality of care provided, care outcomes and older people’s quality of life. Therefore, accurate assessment of GNC is essential for nursing education, workforce development and quality improvement. Although several instruments have been developed to assess GNC, no systematic review has yet comprehensively evaluated their measurement properties.

This protocol is reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. A comprehensive search will be conducted from 1 October 2026 to 1 December 2026 in seven English-language databases and two Chinese-language databases to identify studies reporting the development or evaluation of instruments assessing geriatric nursing competence among nursing personnel. Two reviewers will independently perform study selection, data extraction and methodological quality appraisal. Any disagreements will be resolved through discussion or, if necessary, consultation with a third reviewer. The measurement properties of included instruments will be evaluated using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology.

As this review will include only published or publicly available studies, ethical approval is not required. The findings will be submitted for publication in a peer-reviewed journal and presented at relevant academic conferences.

CRD420261356885.

Impaired inhibitory control is a core neurocognitive deficit in children with attention deficit hyperactivity disorder (ADHD). Physical exercise and mindfulness training are each promising non-pharmacological approaches for ADHD; however, whether combining mindfulness with different exercise modalities, particularly team-based and individual-based open-skill exercise versus closed-skill exercise, yields differential effects on inhibitory control and its neural substrates remains unknown. This study aims to compare these intervention approaches in children with ADHD while exploring associated neural correlates.

This is a single-centre, assessor-blinded and statistician-blinded, three-arm parallel-group randomised controlled trial. 60 children with ADHD aged 6–8 years will be randomly assigned (1:1:1) to one of three 8-week intervention groups: (1) team-based open-skill exercise (basketball) combined with mindfulness training, (2) individual-based open-skill exercise (badminton) combined with mindfulness training or (3) closed-skill exercise (structured aerobic activity) combined with mindfulness training. The co-primary outcomes are behavioural inhibitory control, assessed using the Go/No-Go task and Stroop Colour–Word Test at baseline, postintervention and 3-month follow-up. Secondary outcomes include attention, ADHD symptom severity, executive function, health-related quality of life and resting-state functional MRI indices.

This trial has received ethical approval from the Ethics Committee of the Affiliated Changzhou Children’s Hospital of Nantong University (Approval No.: 2024-029; Approval Date: 2 January 2025) and will be conducted in accordance with the Declaration of Helsinki (2024 revision). The protocol has been prospectively registered with the Chinese Clinical Trial Registry. Findings will be disseminated through peer-reviewed publications and academic conferences.

ChiCTR2500108809.

Ultra-processed food (UPF) reduction has become an increasingly important target in chronic disease prevention and management. Although contemporary dietary guidance has moved towards food-based and skill-oriented approaches, it remains unclear how nurse-delivered education explicitly targeting UPF reduction has been conceptualised, implemented and evaluated in community and outpatient settings. This scoping review aims to map the extent, characteristics and knowledge gaps of evidence on real food-based, nurse-delivered education designed to reduce UPF consumption among adults in community and outpatient chronic disease prevention and management.

This scoping review will be conducted in accordance with the Joanna Briggs Institute (JBI) methodology for scoping reviews and reported in line with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) adapted as appropriate for a scoping review protocol. Eligible evidence sources will include quantitative, qualitative and mixed-methods studies, as well as relevant reviews, programme reports, descriptive papers and text and opinion papers published in English or Chinese. Evidence will be included if it involves adults aged 19 years and older and examines nurse-delivered education explicitly targeting UPF reduction using the NOVA food classification system or an equivalent processing-based operationalisation, while supporting substitution towards unprocessed or minimally processed foods and whole foods, in community or outpatient chronic disease prevention or management contexts. Searches will cover records published from 1 January 2010 to the date of each final database search. Draft searches for the protocol were conducted on 22 February 2026 in selected databases. Final searches will be conducted in MEDLINE (PubMed), the Cumulative Index to Nursing and Allied Health Literature, Embase, Scopus, Web of Science Core Collection and major Chinese databases, supplemented by targeted grey literature searches and citation tracking. Two reviewers will independently screen records, assess full texts and chart data using a piloted data charting tool. Findings will be synthesised descriptively and presented in evidence tables, diagrams and narrative summaries.

Ethical approval is not required because this review will synthesise data from publicly available sources and will not involve primary data collection from human participants. Findings will be disseminated through publication in a peer-reviewed journal, conference presentations and updates to the associated Open Science Framework project.

Open Science Framework registration: https://osf.io/3xakz.

The incidence of silent brain infarction (SBI) and perioperative neurocognitive disorders (PND) is higher in cardiac surgery. However, standard preventive strategies remain unknown due to limited evidence.

This multicentre, prospective, randomised controlled clinical trial with a 1-year follow-up includes patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB). 912 participants are randomly assigned 1:1 into either the intervention group with neuroprotective anaesthesia targets (mean arterial pressure 65–90 mm Hg, bispectral index 40–60, bilateral regional cerebral oxygen saturation ≥60%, arterial inflow temperature

The trial was approved by the Institutional Review Board/Independent Ethics Committee of Fuwai Hospital (Approval No. 2024-2445) and all participating centres. We will disseminate the trial findings in peer-reviewed journals and present the results at national or international conferences.

NCT07048002.

Cancer survivorship places substantial and enduring demands not only on survivors themselves but also on their families and informal caregivers. Family adaptation and family resilience are increasingly recognised as key family-level processes that may alleviate caregiver burden and foster post-traumatic growth (PTG). However, the existing evidence remains fragmented because of inconsistencies in conceptual definitions, theoretical frameworks, study designs and outcome measures.

This scoping review aims to systematically map the existing literature on family adaptation and family resilience among families of cancer survivors, with particular attention to their associations with caregiver burden and post-traumatic growth. The review will clarify key concepts, describe the characteristics and extent of the available evidence and identify knowledge gaps to inform future research and family-centred psychosocial care.

This protocol is guided by the Arksey and O’Malley framework, with subsequent methodological refinements for scoping reviews. A comprehensive search will be conducted in PubMed, Embase, CINAHL, Web of Science, the Cochrane Library, Scopus, China National Knowledge Infrastructure, Wanfang Data, VIP Database and the Chinese Biomedical Literature Database from database inception to 7 January 2026. Grey literature sources, as well as the reference lists of included studies and relevant reviews, will also be searched. Eligibility will be determined using the Population–Concept–Context framework: the population will include family members, family caregivers and informal caregivers of cancer survivors; the concepts will include family adaptation, family resilience, caregiver burden and post-traumatic growth; and the context will encompass cancer survivorship and related care settings. Studies published in English and Chinese will be included with no geographical restrictions. Two reviewers will independently screen studies and extract data using a standardised form, and disagreements will be resolved by a third reviewer. Extracted data will be synthesised descriptively and presented in tables, charts and a narrative summary. The completed scoping review will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews.

Ethics approval is not required because this study will synthesise evidence from published and publicly available sources. The findings will be disseminated through peer-reviewed publication, conference presentations and professional networks.

To investigate the prevalence of depression, anxiety and stress among primary caregivers of children with childhood-onset systemic lupus erythematosus (cSLE) in China and to explore their psychosocial correlates based on the stress process model.

A cross-sectional study.

3 tertiary public hospitals in Hunan Province, China.

242 primary caregivers were invited, and 211 completed the study (87.2% response rate). Convenience sampling was used. Eligible participants were unpaid adult caregivers (aged ≥18 years) of children (aged 1 month. Exclusion criteria included inability to complete questionnaires independently, cognitive impairment due to major physical or mental disorders and current participation in other psychological interventions.

Primary outcomes (depression, anxiety and stress) were measured using the Depression Anxiety and Stress Scale-21. Correlates included threat/challenge appraisal, coping style and perceived social support.

Among 211 caregivers (mean age 40.55±8.22 years; 77.3% female), 31.8% reported depression, 27.0% anxiety and 24.2% stress. Higher threat appraisal was consistently associated with depression (regression coefficients (B) =1.012, p

Caregivers of children with cSLE face substantial psychological distress, with threat perception and negative coping as key modifiable correlates. Interventions to reshape cognitive appraisal and promote adaptive coping, alongside expanded health insurance coverage and optimised caregiving role distribution, are needed to alleviate caregiver burden.