This study aimed to examine the relationship between nursing informatics competencies and clinical decision-making by taking into account nurses' individual characteristics and job-related characteristics. A cross-sectional design was used. The cluster random sampling method was adopted to select 14 governmental hospitals in West Bank, Palestine, in which all nurses in these hospitals were invited to participate in this study. Results found that the total mean (SD) score for the nursing informatics competency scale was 2.6 (0.88), which indicates that the nurses had lower nursing informatics competency, and the informatics skills subscale had the lowest mean score (mean [SD], 2.4 [1.00]). Concerning clinical decision-making, the total mean (SD) score was 2.59 (0.38), which indicates that the nurses had lower clinical decision-making. Regarding clinical decision-making subscales, searching for information and unbiased assimilation of new information had the highest mean score (mean [SD], 2.64 [0.39]); on the contrary, the canvassing of objectives and values subscale had the lowest mean score (mean [SD], 2.53 [0.38]). Nursing informatics competency had a positive relationship with clinical decision-making. Thus, it is necessary to enhance nurses' informatics competency, especially informatics skills and clinical decision-making, by developing training programs about this technology directed to nurses.