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Management controversy and clinical equipoise exist in treatments of long bone fractures and traumatic hip dislocation in paediatric patients due to the lack of high-quality clinical evidence. This protocol describes the effort of a large prospective global multicentre cohort study (registry) aiming at providing quality data to assist evidence-based treatment decision-making.
Eligible paediatric patients (N=750–1000) with open physes suffering from proximal humerus fractures, distal humerus fractures, proximal radius fractures, forearm shaft fractures, traumatic hip dislocations, femoral neck fractures or tibial shaft fractures will be recruited over a period of 24–36 months. Hospitalisation and treatment details (including materials and implants) will be captured in a cloud-based, searchable database. Outcome measures include radiographic assessments, clinical outcomes (such as range of motion, limb length discrepancies and implant removal), patient-reported outcomes (Patient Reported Outcomes Of Fracture, Patient-Reported Outcomes Measurement Information System (PROMIS) and EuroQol-5D (EQ-5D-Y)) and adverse events.
Aside from descriptive statistics on patient demographics, baseline characteristics, types of fractures and adverse event rates, research questions will be formulated based on data availability and quality. A statistical analysis plan will be prepared before the statistical analysis.
Ethics approval will be obtained before patients are enrolled at each participating site. Patient enrolment will follow an informed consent process approved by the responsible ethics committee. Peer-reviewed publication is planned to disseminate the study results.
Chronic malnutrition is a serious problem in southern Angola with a prevalence of 49.9% and 37.2% in the provinces of Huila and Cunene, respectively. The MuCCUA (Mother and Child Chronic Undernutrition in Angola) trial is a community-based randomised controlled trial (c-RCT) which aims to evaluate the effectiveness of a nutrition supplementation plus standard of care intervention and a cash transfer plus standard of care intervention in preventing stunting, and to compare them with a standard of care alone intervention in southern Angola. This protocol describes the planned economic evaluation associated with the c-RCT.
We will conduct a cost-efficiency and cost-effectiveness analysis nested within the MuCCUA trial with a societal perspective, measuring programme, provider, participant and household costs. We will collect programme costs prospectively using a combined calculation method including quantitative and qualitative data. Financial costs will be estimated by applying activity-based costing methods to accounting records using time allocation sheets. We will estimate costs not included in accounting records by the ingredients approach, and indirect costs incurred by beneficiaries through interviews, household surveys and focus group discussions. Cost-efficiency will be estimated as cost per output achieved by combining activity-specific cost data with routine data on programme outputs. Cost-effectiveness will be assessed as cost per stunting case prevented. We will calculate incremental cost-effectiveness ratios comparing the additional cost per improved outcome of the different intervention arms and the standard of care. We will perform sensitivity analyses to assess robustness of results.
This economic evaluation will provide useful information to the Angolan Government and other policymakers on the most cost-effective intervention to prevent stunting in this and other comparable contexts. The protocol was approved by the República de Angola Ministério da Saúde Comité de Ética (27C.E/MINSA.INIS/2022). The findings of this study will be disseminated within academia and the wider policy sphere.
ClinicalTrials.gov Registry (NCT05571280).
Objetivo: Interpretar los antecedentes, atributos y consecuencias asociados al concepto de vejez mediante el método de análisis de concepto de Walker & Avant incorporando la revisión integradora de literatura. Método: estudio de enfoque cualitativo, estudio descriptivo; con el modelo de análisis conceptual de Walker y Avant el cual comprende 8 pasos. Como bases de datos se establece: ProQuest, Redalyc, SAGE, ScienceDirect, Scopus, Medline, Lilacs, Springer, Oxford y Semantic Scholar. Resultados: el mundo actual es muy dinámico y cambiante lo que ha llevado a que significados también se hagan más integradores o ya no mantengan una misma dimensión o pauta para definirse como el hecho de que al sobrepasar cierta edad se estaría viviendo la vejez o el ciclo final de la vida. Conclusiones: La vejez, aunque se identifica generalmente en la dimensión cronológica, como el tiempo vivido en años, en esta revisión se encontraron que hay otros aspectos que dependen de las influencias sociodemográficas mundiales en base a cómo las comunidades asumen diversidad de formas de llegar y aceptar la vejez, en las que se incluyen tres dimensiones más: psicológica, biológica y social.
Objetivo: analizar las ITU en una Residencia y diseñar una estrategia de manejo y prevención. Metodología: estudio descriptivo, retrospectivo y longitudinal de ancianos institucionalizados en una Residencia de Cádiz entre el 1/abril/2015 al 31/marzo/2016. Seleccionamos aquellos que padecieron al menos un episodio de ITU. No presentamos criterios de exclusión. Resultados: contamos con 119 residentes, (media de 88/mes), presentaron infección 44 (75% mujeres). Edad entre 71 y 102 años, moda y mediana de 84. Tasa de incidencia global 49%/año. Sondaje vesical un 15,90% e incontinencia urinaria 86,36%. El 79.1% fueron episodios agudos, 20.9% crónicos y el 68.08% recidivaron. Manifestaciones clínicas: fiebre, astenia, dolor, hiperglucemia y hematuria. Escherichia coli. como germen más habitual. Conclusión: constatamos alta prevalencia de ITU mejorable con estrategia de gestión multidisciplinar, evitando sobrediagnóstico y sobretratamiento y prevención primaria con probióticos.
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