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Assessment of the effectiveness and safety of virtual reality-based telerehabilitation in improving motor function, balance and gait in patients with Parkinsons disease: a protocol for systematic review and meta-analysis

Por: Naqvi · I. W. · Vardhan · V. · Khatib · M. N.
Introduction

Virtual reality-based telerehabilitation (VR-TR) combines gamified exercises with remote supervision for people with Parkinson’s disease (PD). Its effectiveness and safety in PD remain uncertain. This protocol outlines methods to evaluate the effects of VR-TR on functional and clinical outcomes.

Methods and analysis

Randomised controlled trials and quasi-experimental studies will be identified in PubMed (National Library of Medicine), Scopus (Elsevier), Cochrane CENTRAL (Cochrane Library) and PEDro (Physiotherapy Evidence Database) from inception to June 2026, with additional searches of grey literature and trial registries. Eligible participants are adults with idiopathic PD. Interventions include immersive or non-immersive VR-TR with remote supervision, compared with conventional physiotherapy, usual care or other active non-VR interventions. Primary outcomes are balance, gait and global motor function; secondary outcomes are quality of life and adverse events. Two reviewers will independently screen, extract data and assess risk of bias. Where possible, meta-analyses will be conducted using RevMan V.5.4, and the certainty of evidence will be appraised with Grading of Recommendations Assessment, Development and Evaluation.

Ethics and dissemination

This study does not involve human participants and uses data from published studies; therefore, ethics approval is not required. However, as per institutional requirements, ethical clearance was obtained from the Institutional Ethics Committee of Datta Meghe Institute of Higher Education and Research (DMIHER) (Ref. No.: DMIHER(DU)/IEC/2025/204). Findings will be published in peer-reviewed journals and presented at conferences.

PROSPERO registration number

CRD420251009423.

Gender differences in clinical features, comorbidities and prognostic outcomes in idiopathic pulmonary fibrosis--a retrospective cohort analysis from the British Thoracic Society Interstitial Lung Disease Registry

Background

Idiopathic pulmonary fibrosis (IPF), an unknown aetiology type of interstitial lung disease (ILD), carries the poorest prognosis and is more common in males and the elderly. Gender differences in baseline presentation, lung function and comorbidities may have an impact on prognostic outcomes.

Objective

The aim of this study was to explore gender differences in clinical features, comorbidities and outcomes in IPF in a UK cohort.

Method

This was a retrospective cohort study analysing data from the British Thoracic Society UK IPF ILD Registry from January 2013 to February 2024. We compared baseline characteristics between males and females, and a survival analysis in both genders was performed using the Cox proportional hazards model.

Results

We identified 6666 IPF patients with a mean age at diagnosis of 74.1±8.1. Our cohort was predominantly male (5197, 78%), with a higher proportion of current and ex-smokers compared with females (69.9% vs 59.9%, p

Conclusion

Gender differences in baseline characteristics and prognostic factors were observed in IPF. A gender-based approach in managing IPF is warranted, and further studies are needed to clarify these differences and their impact on IPF management.

Exposure to Violence for Nurses Across Ethnic Groups: A Qualitative Study

ABSTRACT

Aim

To explore the social context of violence for hospital-based and community nurses from different ethnic groups, the types of violence experienced or witnessed both in and outside the workplace, and its impact on mental and physical health.

Design

Cross-sectional, qualitative study using semi-structured interviews.

Methods

Semi-structured interviews were conducted online with 12 hospital-based and community nurses recruited from London, England, between May and August 2021. Data were analysed using reflexive thematic analysis.

Results

The sample comprised seven hospital nurses and five community nurses. Four themes were identified: (i) the social context in which nurses from different ethnic groups are exposed to community violence; (ii) types of workplace violence experienced or witnessed by hospital-based and community nurses from different ethnic groups; (iii) perceptions of the factors contributing to workplace violence; (iv) impacts of violence on mental and physical health outcomes. Using the social ecological framework and sociological theory of stress, these findings informed a conceptual stress process model of violence exposure for nurses.

Conclusion

Nurses from different ethnic groups are exposed to violence both in and outside the workplace which negatively affects their mental and physical health. Effective violence prevention requires a multi-factorial approach that addresses the social and institutional factors contributing to violence, shifting the focus from individual measures to systemic organisational changes.

Impact

The NHS workforce is currently more diverse than ever, and healthcare leaders must improve access to mental health and well-being resources for staff affected by workplace violence, particularly for those who hold multiple social identities at the intersection of ethnicity, gender and age. Prioritising this support is essential not only to safeguard against negative health outcomes but also to improve the recruitment and retention of healthcare professionals.

Patient or Public Contribution

No patient or public contribution.

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