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To investigate the effectiveness of antimicrobial agents against wound infections, experiments using either 2D cultures with planktonic microorganisms or animal infection models are frequently carried out. However, the transferability of the results to human skin is limited by the lack of complexity of the 2D models or by the poor translation of the results from animal models. Hence, there is a need for wound infection models capable of assessing antimicrobial agents. In this study, an easily standardized wound infection model was established. This model consists of a mechanically wounded human skin model on a collagen matrix infected with various clinically relevant bacteria. Infection of the model led to recognition of the pathogens and induction of an inflammatory response. The untreated infection spread over time, causing significant tissue damage. By applying an antimicrobial-releasing wound dressing, the bacterial load could be reduced and the success of the treatment could be further measured by a decrease in the inflammatory reaction. In conclusion, this wound infection model can be used to evaluate new antimicrobial therapeutics as well as to study host-pathogen interactions.
To analyse the content of the nursing diagnosis ineffective peripheral tissue perfusion in patients with diabetic foot.
A methodological study with a quantitative approach was performed.
The analysis was performed between January and May 2021 by 34 nurses with clinical/theoretical/research experience with diabetes or nursing diagnoses. These nurses evaluated the relevance, clarity and precision of 12 diagnosis-specific etiological factors, 22 clinical indicators and their conceptual and operational definitions.
All 12 etiological factors analysed were considered relevant to diagnostic identification. However, five showed inconsistencies regarding the clarity or precision of the operational definitions, requiring adjustments. Regarding the 22 clinical indicators evaluated, all of them presented a Content Validity Index (CVI) that was statistically significant. However, in the indicators, the colour does not return to lowered limb after 1 min of leg elevation, and cold foot had Content Validity Index (CVI) <0.9 regarding relevance and accuracy of operational definitions.
Twelve etiological factors and 22 clinical indicators were validated. Thus, this study revealed new and relevant aspects characterising peripheral perfusion in patients with diabetic foot that have not yet been clinically validated.
This study contributes to support the professional practice of nurses through the early identification of etiological factors and clinical indicators in persons with diabetic foot. As a proposal, we suggest the inclusion of new defining characteristics and related factors for the nursing diagnosis ineffective peripheral tissue perfusion in the NANDA-I taxonomy.
The research highlights new and relevant aspects such as etiological factors and clinical indicators to characterise peripheral perfusion in patients with diabetic foot. Based on these findings, clinical validation is recommended to confirm the relevance of the proposed elements in the population studied for greater reliability and improved diagnostic assessment for the professional practice of nurses.
EQUATOR guidelines were adhered to using the GRRAS checklist for reporting reliability and agreement studies.
No patient or public contribution.
Nonadherence to therapy negatively impacts mortality and quality of life and results in suboptimal efficacy of treatment regimens, threats to patient safety, and increased healthcare costs for disease management. Mobile health solutions can offer users instruments that can promote therapeutic adherence. The objective of this review is to investigate the impact mobile health systems have on therapeutic adherence. Specifically, we want to map the main systems used, the functions implemented, and the different methods of adherence detection used. For this purpose, a scoping review was conducted. The following databases were consulted: PubMed, Cochrane Library, EBSCO (including APA PsycINFO, CINAHL Plus with Full Text, ERIC), including English-language studies published in the last 10 years (2012–2022). The main mobile health systems used are as follows: applications, automated messaging, interactive voice response, and mobile video games. The main features implemented to support medication management were as follows: reminders, self-monitoring instruments, educational support, and caregiver involvement. In conclusion, the use of interactive mobile health instruments intended for use by the patient and/or caregiver can improve objectively and subjectively detected therapeutic adherence. The use of these systems in the therapeutic pathway of users, with a special focus on people with comorbidities and in polypharmacy treatment, represents a challenge to improve caregiver health. by Nicolas Dollion, Margot Poirier, Florian Auffret, Nathe François, Pierrich Plusquellec, Marine Grandgeorge, Handi’Chiens , Fondation Mira
The integration of a service dog can have numerous benefits for children with Autism Spectrum Disorder (ASD). However, although integration takes place within a family, little is known about the dynamics of these benefits on the family microsystem. Thus, the aim of our study was to propose a more systemic perspective, not only by investigating the benefits of SD integration, but also by exploring the relationships between improvements in children with ASD, parents’ well-being, parenting strategies and the quality of the child-dog relationship. Twenty parent-child with ASD dyads were followed before, as well as 3 and 6 months after service dog integration. At each stage, parents completed an online survey which included: the Autism Behavior Inventory (ABI-S), the State-Trait Anxiety Inventory (STAI-Y), the Parenting Stress Index Short Version (PSI-SF), the Monash Dog Owner Relationship Scale (MDORS) and the Parenting Styles and Dimensions Questionnaire (PSDQ). First, repeated measure one-way ANOVAs revealed that both children’s ASD symptoms and parents’ anxiety decreased significantly after service dog integration. Additionally, Spearman correlations revealed that the more ASD symptoms decreased, the more parent’s anxiety and parenting stress also decreased. Second, the quality of the child-dog relationship appeared to contribute to those benefits on both children’s ASD symptoms and parents’ well-being. Interestingly, parenting strategies seemed to adapt according to these benefits and to the quality of the child-dog relationship. Through a more systemic perspective, this study highlighted that the integration of a service dog involved reciprocal and dynamic effects for children with ASD and their parents, and shed new light on the processes that may underlie the effects of a service dog for children with ASD.Research on structural empowerment has typically adopted a variable-centered perspective, which is not ideal to study the combined effects of structural empowerment components. This person-centered investigation aims to enhance our knowledge about the configurations, or profiles, of healthcare employees' perceptions of the structural empowerment dimensions present in their workplace (opportunity, information, support, and resources). Furthermore, this study considers the replicability and stability of these profiles over a period of 2 years, and their outcomes (perceived quality of care, and positive and negative affect).
Participants completed the same self-reported questionnaires twice, 2 years apart.
A sample of 633 healthcare employees (including a majority of nurses and nursing assistants) participated. Latent transition analyses were performed.
Five profiles were identified: Low Empowerment, High Information, Normative, Moderately High Empowerment, and High Empowerment. Membership into the Normative and Moderately High Empowerment profiles demonstrated a high level of stability over time (79.1% to 83.2%). Membership in the other profiles was either moderately stable (43.5% for the High Empowerment profile) or relatively unstable (19.7% to 20.4% for the Low Empowerment and High Information profiles) over time. More desirable outcomes (i.e., higher positive affect and quality of care, and lower negative affect) were observed in the High Empowerment profile.
These results highlight the benefits of high structural empowerment, in line with prior studies suggesting that structural empowerment can act as a strong organizational resource capable of enhancing the functioning of healthcare professionals. These findings additionally demonstrate that profiles characterized by the highest or lowest levels of structural empowerment were less stable over time than those characterized by more moderate levels.
From an intervention perspective, organizations and managers should pay special attention to employees perceiving low levels of structural empowerment, as they experience the worst outcomes. In addition, they should try to maintain high levels of structural empowerment within the High Empowerment profile, as this profile is associated with the most desirable consequences. Such attention should be fruitful, considering the instability of the High Empowerment and Low Empowerment profiles over time.
NCT04010773 on ClinicalTrials.gov (4 July, 2019).
The aim of this study was to systematically consolidate evidence on perspectives and thoughts of women living with HIV regarding the peer support they have encountered during pregnancy and after childbirth.
Mixed studies systematic review.
PubMed, EMBASE, Cochrane, PsycINFO, CINAHL, Scopus and ProQuest were sourced from 1981 to January 2022.
A convergent qualitative synthesis approach was used to analyse the data. Quality appraisal was performed using the Mixed Methods Appraisal Tool.
A total of 12 studies were included, involving 1596 pregnant women and 1856 new mothers living with HIV. An overarching theme, ‘From One Mother to Another: The Supportive Journey of Pregnant Women and New Mothers Living with HIV’, and two themes were identified: (1) Emotional support buddies and extended networks and (2) Link bridge to healthcare support and self-empowerment.
Peer support played an indispensable role in the lives of women living with HIV and served as a complementary support system to professional and family support.
What problem did the study address? Pregnant women and new mothers living with HIV face preconceived stigma and discrimination.
What were the main findings? Peer support was perceived to be beneficial in enhancing emotional support among women living with HIV and was well-accepted by them.
Where and on whom will the research have an impact? Healthcare providers and community social workers could develop or enhance peer support educational programmes tailored to pregnant women and new mothers living with HIV. Policymakers and administrators can leverage public awareness, advocacy and political will to formulate and implement policies and campaigns aimed at fostering awareness and receptivity towards peer support interventions.
Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA).
No patient or public contribution.
The RESPIRA cohort aims to describe the nature, magnitude, time course and efficacy of the immune response to SARS-CoV-2 infection and vaccination, population prevalence, and household transmission of COVID-19.
From November 2020, we selected age-stratified random samples of COVID-19 cases from Costa Rica confirmed by PCR. For each case, two population-based controls, matched on age, sex and census tract were recruited, supplemented with hospitalised cases and household contacts. Participants were interviewed and blood and saliva collected for antibodies and PCR tests. Participants will be followed for 2 years to assess antibody response and infection incidence.
Recruitment included 3860 individuals: 1150 COVID-19 cases, 1999 population controls and 719 household contacts from 304 index cases. The age and regional distribution of cases was as planned, including four age strata, 30% rural and 70% urban. The control cohort had similar sex, age and regional distribution as the cases according to the study design. Among the 1999 controls recruited, 6.8% reported at enrolment having had COVID-19 and an additional 12.5% had antibodies against SARS-CoV-2. Compliance with visits and specimens has been close to 70% during the first 18 months of follow-up. During the study, national vaccination was implemented and nearly 90% of our cohort participants were vaccinated during follow-up.
RESPIRA will enable multiple analyses, including population prevalence of infection, clinical, behavioural, immunological and genetic risk factors for SARS-CoV-2 acquisition and severity, and determinants of household transmission. We are conducting retrospective and prospective assessment of antibody levels, their determinants and their protective efficacy after infection and vaccination, the impact of long-COVID and a series of ancillary studies. Follow-up continues with bimonthly saliva collection for PCR testing and biannual blood collection for immune response analyses. Follow-up will be completed in early 2024.
by Ann S. Lauterbach, Tobias Tober, Florian Kunze, Marius R. Busemeyer
Many workers are experiencing the downsides of being exposed to an overload of information and communication technology (ICT), highlighting the need for resources to cope with the resulting technostress. This article offers a novel cross-level perspective on technostress by examining how the context of the welfare state influences the relationship between income and technostress. Showing that individuals with higher income experience less technostress, this study argues that the welfare state represents an additional coping resource, in particular in the form of unemployment benefits. Since unemployment benefits insure income earners in the case of job loss, the negative effect of income on technostress should increase with higher levels of unemployment generosity. In line with these expectations, empirical results based on original survey data collected in collaboration with the OECD show that the impact of income on technostress varies across welfare state contexts. Implications for public health and policymakers are being discussed.by Gerben A. van Kleef, Florian Wanders, Annelies E. M. van Vianen, Rohan L. Dunham, Xinkai Du, Astrid C. Homan
Norms play an important role in upholding orderly and well-functioning societies. Indeed, violations of norms can undermine social coordination and stability. Much is known about the antecedents of norm violations, but their social consequences are poorly understood. In particular, it remains unclear when and how norm violators gain or lose influence in groups. Some studies found that norm violators elicit negative responses that curtail their influence in groups, whereas other studies documented positive consequences that enhance violators’ influence. We propose that the complex relationship between norm violation and influence can be understood by considering that norm violations differentially shape perceptions of dominance and prestige, which tend to have opposite effects on voluntary influence granting, depending on the type of norm that is violated. We first provide correlational (Study 1) and causal (Study 2) evidence that norm violations are associated with dominance, and norm abidance with prestige. We then examine how dominance, prestige, and resultant influence granting are shaped by whether local group norms and/or global community norms are violated. In Study 3, protagonists who violated global (university) norms but followed local (sorority/fraternity) norms were more strongly endorsed as leaders than protagonists who followed global norms but violated local norms, because the former were perceived not only as high on dominance but also on prestige. In Study 4, popular high-school students were remembered as violating global (school) norms while abiding by local (peer) norms. In Study 5, individuals who violated global (organizational) norms while abiding by local (team) norms were assigned more leadership tasks when global and local norms conflicted (making violators “rebels with a cause”) than when norms did not conflict, because the former situation inspired greater prestige. We discuss implications for the social dynamics of norms, hierarchy development, and leader emergence.Se estima que la artrosis puede darse en un 10% de la población española. Los principales síntomas son el dolor mecánico, la rigidez, así como la incapacidad de tipo funcional. El tratamiento irá dirigido fundamentalmente a la mejoría del dolor, pero es primordial educar al paciente en la adopción de conductas que impidan la progresión de la enfermedad. Se ha llevado a cabo una revisión crítica (CAT), para tratar de dar respuesta a la siguiente pregunta clínica: ¿La praxis de yoga en pacientes con diagnóstico de artrosis provoca una disminución del dolor? Tras realizar una búsqueda avanzada en la base de datos Epistemonikos en el mes de noviembre del año 2021, han sido tres las referencias finales incluidas en este trabajo. El resultado principal determinó que la práctica de yoga tiene efectos positivos en el alivio del dolor de pacientes con osteoartritis a diferentes niveles, considerándose una práctica segura y adaptable.
Objetivo principal: Evidenciar la seguridad del inicio de vasopresores mediante un catéter venoso periférico corto en pacientes adultos con diagnóstico de choque séptico, a través de la metodología Enfermería Basada en Evidencia. Metodología: Revisión sistemática. La búsqueda de evidencia se realizó en dos periodos, del 15 al 23 de septiembre del 2022 y del 3 al 20 de octubre del 2022, se utilizaron fuentes de búsqueda e información: base de datos PubMed y el buscador Google académico. Resultados principales: Se evaluaron 19679 pacientes, el tiempo de administración de la infusión fue de 101.05 horas, con una duración media de 22.63 horas, el evento adverso con más incidencia fue la extravasación con duración media de 7.5 horas, el vasopresor más utilizado fue la norepinefrina. Conclusión principal: Administrar vasopresores por vía periférica es seguro, considerando factores que reducirían significativamente el riesgo de complicaciones.
Objetivo: Conocer la percepción del liderazgo de enfermería desde las relaciones de poder, a partir de la opinión de las enfermeras, enfermeros recién titulados e integrantes del equipo de salud. Método: Investigación cualitativa, de tipo estudio de caso, con enfoque fenomenológico. Desarrollada en dos fases, aprobado por un comité de ética. Los participantes fueron enfermeras y enfermeros recién titulados e integrantes del equipo de salud. Se realizó muestreo por conveniencia, aplicación de entrevistas semiestructuradas, análisis de contenido y aplicación de pauta COREQ-32. Resultados: La categoría relaciones de poder da cuenta de una evolución histórica del liderazgo de enfermería y la existencia de relaciones de poder dentro del equipo de salud relacionado con profesión, género, diferencias generacionales y jerarquías administrativas. Conclusión: Se devela la existencia de relaciones de poder que influencian el ejercicio del liderazgo de enfermería, lo que ha obstaculizado la participación de enfermería en cargos directivos, precisando fortalecer las capacidades de liderazgo de enfermería.
La esclerosis múltiple (EM) es la primera causa de discapacidad en adultos jóvenes. A pesar de su relevancia epidemiológica, no son claras las intervenciones de cuidado que realizan los profesionales de la salud para evitar la remisión de brotes de la enfermedad (independientemente del tratamiento farmacológico). Por lo tanto surge la siguiente pregunta ¿Qué intervenciones en los últimos cinco años realizan los profesionales de salud para la toma de decisiones sobre el cuidado humano en personas con EM? Metodología. Revisión sistemática, se consultaron las principales bases de datos con palabras clave en tres idiomas. Resultados principales: de 2093 artículos se excluyeron 1870 por título y se eliminaron 176 por resumen. Conclusión: Los artículos provienen principalmente de psicología, enfermería y medicina. Las principales intervenciones versaron en ejercicio, temáticas cognitivas, rehabilitación, cuidados paliativos, continuidad de cuidados y manejo de fatiga crónica. La información resulta importante para las disciplinas de salud, sobre todo para enfermería, al liderar un cuidado más cercano y de calidad en personas con EM.
Objetivos: determinar los indicadores de morbilidad de la tuberculosis en una ciudad del nordeste brasileño prioritaria para el control de la enfermedad y describir características sociodemográficas y clínicas-epidemiológicas de los casos notificados. Método: se trata de un estudio epidemiológico descriptivo con enfoque cuantitativo, considerando todos los casos notificados mediante el Sistema Nacional de Información y Agravios de Notificación en 2015 y expresando los coeficientes de incidencia y prevalencia. Las variables relacionadas con la caracterización sociodemográfica tales como género, edad, raza/color, nivel de educación y zona de residencia, así como las de investigación clínica-epidemiológica, tipo de ingreso, forma clínica, realización de baciloscopía, cultivo, realización de tratamiento supervisado y desenlace de tratamiento fueron analizadas por medio de la estadística descriptiva. Resultados: las tasas de prevalencia e incidencia fueron respectivamente 26,0 y 24,5 casos/100.000 habitantes, donde la mayoría de los casos notificados pertenecían a la zona urbana (98,48%), haciendo hincapié en hombres (68,18%), con edades ≤ 40 años (60%), raza/color pardo (78,79%) y con el predominio de la enseñanza primaria completa (34,85%). En lo que atañe a las características clínicas y epidemiológicas, la mayoría presentaba la forma clínica pulmonar (89,39%), resaltando la baciloscopía de esputo positivo (40,91%), cultivo de esputo no realizada (92,42%), rayos-x torácicos sospechosos para tuberculosis (54,55%), enfermedades y agravios – SIDA (10,61%), y la situación de desenlace predominante fue la cura (86,36%). Conclusiones: a pesar del panorama epidemiológico evidenciado con indicadores de morbilidad por debajo del promedio nacional, la identificación del perfil clínico-epidemiológico de la población afectada señaló aspectos importantes que deben ser observados relacionados con la organización de los sistemas y servicios sanitarios para el control y vigilancia de esta enfermedad.
Objetivo: identificar los elementos teóricos y metodológicos del cuidado que aplican los profesionales de enfermería en dos instituciones de salud del Departamento del Atlántico. Metodología: estudio descriptivo, transversal, la muestra estuvo conformada por 60 enfermeras de dos instituciones de salud. La obtención de datos se realizó a través de un cuestionario, consignándose las variables significativas, el análisis de los datos se calcularon en frecuencias absolutas y porcentajes. Resultados: predominó el grupo etario de 23 a 27 años: 43%, el género femenino: 100%, el 76% señalaron dificultades en la aplicación; Modelos de Enfermería orientadores de la práctica: Dorotea Orem: 78%; en la Aplicación de teorías Florence Nightingale: 73%, entre otros. Conclusión: Las enfermeras señalan que sí recibieron en el pregrado conocimientos sobre el tema, pero en la práctica algunas no los aplican; situación preocupante, debida a que no se reconoce la importancia de los principios científicos y filosóficos que orientan la profesión.
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