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Ayer — Octubre 2nd 2025Tus fuentes RSS

Assessing the impact of the COVID-19 pandemic among internally displaced persons in Burkina Faso, Mali and Niger: a cross-sectional study using respondent-driven sampling

Por: Pham · P. N. · Keegan · K. · Johnston · L. G. · Diallo · D. Y. · OMealia · T. · Goh · M. · Vinck · P.
Objectives

Documenting evidence on global health strategies and programmes that provide safeguards for vulnerable populations and strengthen overall pandemic preparedness is essential. This study aimed to identify factors associated with adherence to COVID-19 mitigation measures, COVID-19-related symptoms and testing, as well as pandemic-related income loss among internally displaced persons (IDPs) in urban and remote areas of Burkina Faso, Niger and Mali.

Design

This cross-sectional study used fixed-site respondent-driven sampling (RDS).

Setting

Primary care settings across six urban and remote locations in Burkina Faso, Mali and Niger.

Participants

4144 internally displaced adults, who had been forced from their homes within 5 years of the survey, participated in the study. The survey was conducted between August and October 2021 in two selected locations in three countries: Kaya (n=700) and Ouahigouya (n=715) in Burkina Faso; Bamako (n=707) and Ménaka (n=700) in Mali; and Niamey (n=733), and Diffa (n=589) in Niger. Participants were included if they were born in the study countries, displaced due to conflict, violence or disaster, aged 18 years or older, and living or working in the study site for at least 1 month.

Primary and secondary outcome measures

The primary outcomes measured were adherence to COVID-19 mitigation measures, presence of COVID-19 symptoms, COVID-19 testing and vaccination rates and pandemic-related income loss.

Results

Among 4144 IDPs surveyed across 6 sites in Burkina Faso, Mali and Niger, over half (52%) reported experiencing at least one COVID-19 symptom in the preceding 2 weeks. However, 8% had ever been tested for COVID-19, and fewer than 5% had received a vaccine in all sites except Diffa, where 54% reported vaccination. While willingness to be vaccinated was high (ranging from 56.6% in Bamako to 89.5% in Niamey), access remained limited. Compliance with public health measures varied; for example, 41.7% of IDPs were able to maintain physical distance from non-household members, and just 60.2% reported wearing a mask. Chronic health conditions were consistently associated with higher odds of COVID-19 symptoms (Ménaka OR: 14.65; 95% CI: 7.36 to 29.17). Economic vulnerability was widespread, with more than half of IDPs in Bamako (58.1%) and Niamey (66.4%) reporting income loss due to the pandemic, and average monthly income declining by over 50% in most sites. IDPs in urban areas generally reported greater exposure to COVID-19 risk factors, while those in remote settings reported lower adherence and poorer access to basic preventive measures.

Conclusions

This is the first known RDS study to explore the impact of the COVID-19 pandemic on IDPs. Findings suggest that IDPs in urban areas may face heightened risks of exposure and infection, underscoring the need to prioritise them in public health efforts. Low testing and vaccination rates and significant income loss call for advocacy and economic relief to address these vulnerabilities. Future pandemic responses should integrate health interventions with targeted support, especially mitigating income loss to bolster IDPs’ resilience.

AnteayerTus fuentes RSS

Putting the patient at the centre: a call for research involvement of nurses, midwives and allied health professionals working in genomics

Por: Cowley · L. · Henriques · S. · Roberts · J. · Monje-Garcia · L. · Nolan · J. · Lubasch · K. · Theobald · R. · Greer · R. · Fennell · N. · Clarkson · A. · Clapham · M. · Chilton · S. · Allon · R. · Stopford · C. · Pierce · H. H. · Holliday · D.
Introduction

We report the collaborative views of a group of nurses, midwives and allied health professionals (NMAHPs) in the UK who have a genomics research remit or interest. Our group includes genetic counsellors under this diverse category of healthcare workers.

This group came together as part of the National Institute for Health and Social Care Research (NIHR) Genomics Research National Specialty Group. After responding to a survey to elicit the views of NMAHPs working in genomics, some of the original 45 respondents, along with others who learnt of the project by word of mouth, have worked together to produce this article.

Objective

The paper aims to set out in clear terms the value of NMAHPs to research that supports the patient-centred implementation of genomics in the National Health Service (NHS).

Key argument

We discuss four potential areas where NMAHPs, in particular, can contribute to the research. These are patient perspectives and epistemic justice, psychosocial impacts, the familial nature of genomics and equity. We argue that this group (NMAHPs) represents a potentially underused resource for the NHS as it seeks to ensure that advances in genomics are translated into patient benefit.

Conclusions

We propose that NMAHPs, with our research expertise, are well placed to shape and deliver a research agenda that explores models of patient-centred care in the genomics era. We call for increased funding for NMAHP research roles and funding opportunities to deliver this fundamental work.

Effects of 810 nm treatments in acute myofiber contraction of C2C12 myotubes

by Nashwa Cheema, Linh Pham, Alexa Nazarian, Namrata Ghag, Emma Wise, Christiane Fuchs, Richard Rox Anderson, Joshua Tam

The muscoskeletal system can be irradiated with wavelengths in the red and near infrared regions which penetrate deep into the body and stimulate biological mechanisms. However, the activation of cellular responses in muscle, specifically actively contracting, is not clearly understood. Therefore, we investigated biological effects induced by irradiation with 810 nm wavelength of light in myotubes, resting or actively contracting in an acute model of exercise. In resting myotubes, cytosolic Ca2+ rose within 10 minutes post treatment with 810 nm at 2–4 J/cm2. ATP production was increased 4% ± 3 at 24 hrs post light treatment. In contracting myotubes, 810 nm treatment resulted in a significant ~30% increase in intracellular ATP levels and a 20% ± 12 reduction in lactate secretion into cell culture media. 810 nm treated myotubes also had a smaller change in myotube width during contractions, 5% ± 3, suggesting the myotubes were contracting with less force. Although the contractile motion was reduced, 810 nm treated myotubes had a higher frequency of spontaneous contractions after removal of electric pulse stimulation (EPS), 42% ± 21 and 1.3-2 – fold increase in mitochondrial proteins, Tom70, citrate synthase (CS) and succinate dehydrogenase (SDHA). This finding suggests that 810 nm treatment altered metabolic and contractile properties of myotubes due to mitochondrial activation. A more thorough understanding of these effects could lead to new treatment modalities that could improve physical performance.

Geriatric ocular trauma and mortality: A retrospective cohort study

by Vincent Q. Pham, Hannah M. Miller, Elise O. Fernandez, Daniel de Marchi, Elizabeth Budi, Hongtu Zhu, David Fleischman

Purpose

The objective of this investigation is to evaluate the 5-year mortality of geriatric patients who have sustained eye injuries.

Design

This retrospective cohort study included patients aged 65 years or older who had histories of either ocular trauma or age-related nuclear cataracts.Subjects and controls: Patients with ocular trauma constituted the study group, while those with a history of cataracts served as controls.

Methods

Data from the I2B2 Carolina Data Warehouse were analyzed. Patient demographics were collected, and the outcomes of interest were the overall mortality rate and annual mortality rates over a 5-year period. Chi-squared tests were utilized for the comparison of mortality data.

Main outcomes and measures

The primary outcomes were overall mortality rates and annual mortality rates expressed as percentages.

Results

The study group consisted of 602 patients who had suffered ocular trauma. The control group included 1066 patients of similar age who had been diagnosed with age-related nuclear cataracts at some point in their lives. Among the study group, 74 patients died within 5 years, while 69 patients in the control group died within the same timeframe, resulting in a study group mortality rate of 11.30% and a control group mortality rate of 6.47%. For patients with ocular trauma, the annual mortality rates were 4.15%, 2.60%, 1.96%, 2.54%, and 0.56%, respectively. For the control group, the annual mortality rates were 1.03%, 1.70%, 1.64%, 0.88%, and 1.38% respectively.

Conclusion

The study suggests that geriatric patients who have experienced ocular trauma are at a higher risk of mortality compared to age-matched controls without such injuries. These findings highlight the necessity of identifying the causes of geriatric periorbital trauma and underscore the importance of close patient follow-up to improve outcomes.

Framework to guide the use of mathematical modelling in evidence-based policy decision-making

Por: Oliwa · J. · Guleid · F. H. · Owek · C. J. · Maluni · J. · Jepkosgei · J. · Nzinga · J. · Were · V. O. · Sim · S. Y. · Walekhwa · A. W. · Clapham · H. · Dabak · S. · KC · S. · Hadley · L. · Undurraga · E. · Hagedorn · B. L. · Hutubessy · R. C.
Introduction

The COVID-19 pandemic highlighted the significance of mathematical modelling in decision-making and the limited capacity in many low-income and middle-income countries (LMICs). Thus, we studied how modelling supported policy decision-making processes in LMICs during the pandemic (details in a separate paper).

We found that strong researcher–policymaker relationships and co-creation facilitated knowledge translation, while scepticism, political pressures and demand for quick outputs were barriers. We also noted that routine use of modelled evidence for decision-making requires sustained funding, capacity building for policy-facing modelling, robust data infrastructure and dedicated knowledge translation mechanisms.

These lessons helped us co-create a framework and policy roadmap for improving the routine use of modelling evidence in public health decision-making. This communication paper describes the framework components and provides an implementation approach and evidence for the recommendations. The components include (1) funding, (2) capacity building, (3) data infrastructure, (4) knowledge translation platforms and (5) a culture of evidence use.

Key arguments

Our framework integrates the supply (modellers) and demand (policymakers) sides and contextual factors that enable change. It is designed to be generic and disease-agnostic for any policy decision-making that modelling could support. It is not a decision-making tool but a guiding framework to help build capacity for evidence-based policy decision-making. The target audience is modellers and policymakers, but it could include other partners and implementers in public health decision-making.

Conclusion

The framework was created through engagements with policymakers and researchers and reflects their real-life experiences during the COVID-19 pandemic. Its purpose is to guide stakeholders, especially in lower-resourced settings, in building modelling capacity, prioritising efforts and creating an enabling environment for using models as part of the evidence base to inform public health decision-making. To validate its robustness and impact, further work is needed to implement and evaluate this framework in diverse settings.

Patient Experiences of Receiving Stroke Discharge Information in Accordance With Preferences

ABSTRACT

Aims

To examine survivors' experiences of discharge information including risk communication after hospitalisation for a stroke and the characteristics associated with receiving information in accordance with their preferences.

Background

With advances in acute stroke care and an ageing population, the number of survivors of stroke is increasing. It is important that healthcare providers ensure patients have adequate information after a stroke-related hospitalisation.

Design

Cross-sectional study.

Methods

Adults recently discharged after a stroke from eight Australian hospitals were mailed a survey. Items examined risk and discharge care information, with participants asked to indicate both their preferences for and receipt of the information. Concordance with preferences was calculated, and characteristics associated with information preference concordance were assessed with binomial logistic regression. Study reported in accordance with STROBE Checklist.

Results

Of 1161 eligible patients invited, 403 (35%) completed the survey. All items were endorsed by 80% or more of respondents as being wanted. However, for all items, fewer respondents reported the care as received. Only 28% of participants received information on all five items according to their preferences. Hospital site, Body Mass Index and age were statistically significantly associated with participants receiving information in accordance with their preferences.

Conclusion

Most participants indicated a preference to receive recommended discharge information. Findings suggest that patients may benefit from increased information provision prior to hospital discharge after stroke.

Relevance to Clinical Practice and Patient Care

Nurses have an important role in the provision of stroke care and information. The findings of this study may be used to improve the provision of post-hospital discharge care and support for survivors of stroke, and assist in identifying patients at lower odds of experiencing information aligned with their preferences and who may benefit from support.

Reporting Method

Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist for cross-sectional studies.

Patient or Public Contribution

No patient or public contribution.

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