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Adverse childhood experience among patients with severe mood disorders in Gedeo Zone Public Hospitals, Southern Ethiopia:A multisite cross-sectional study

Por: Mekuriaw · B. Y. · Amede · E. S. · Shono · M. N.
Objective

To assess prevalence and associated factors of adverse childhood experiences (ACEs) among patients with severe mood disorders (SMDs).

Design

An institution-based cross-sectional study.

Setting

Gedeo Zone Public Hospitals, Southern Ethiopia.

Participants

374 patients with SMDs were recruited using a systematic sampling technique.

Primary and secondary outcome measures

The data were collected using an interview-administered questionnaire and medical chart review. The outcome variable was assessed using the ACEs questionnaire. Data were coded and entered into Epi Data 3.1 and analysed using SPSS V.26. Bivariate and multivariable logistic regression analyses were performed to identify factors associated with ACEs. The presence of an association was examined using an adjusted OR (AOR) with a 95% CI. Variables with P-values less than 0.05 were considered a statistically significant association.

Results

The overall prevalence of ACEs among patients with SMDs was 51.6% (95% CI 49.2 to 53.9), and the prevalence of ACEs among patients with severe bipolar disorders and depressive disorders was 14.7% with (95% CI 46.8 to 52.4) and 36.9% with (95% CI 46.7 to 55.8), respectively. Having low socioeconomic status (SES) (AOR=2.04 (95% CI 1.40 to 3.45), poor social support (AOR=2.43 (95% CI 1.74 to 4.17)), low resilient coping strategies (AOR=1.48 (95% CI 1.21 to 2.83)) and severity of depressive symptoms (AOR=3.82 (95% CI 2.89 to 6.00)) were significantly associated with ACEs.

Conclusion

This study reveals a high prevalence of ACEs among patients with SMDs, with more than half of the participants reporting at least one ACE. Low SES, low resilient coping strategies and poor social support were factors significantly associated with ACEs, and severe depressive symptoms were significantly associated with ACEs. Therefore, these findings underscore the importance of early screening and appropriate intervention for SMDs and ACEs, and providing more holistic mental healthcare for SMDs and ACEs, improving access to education and economic support, strengthening social support networks, enhancing resilience-building programmes and integrating routine ACEs assessments into mental health evaluations could potentially contribute to improved clinical outcomes and support long-term recovery.

Trial registration

Not applicable

Preoperative anaemia and its impact on immediate surgical outcomes in elderly patients: a multicentre prospective cohort study in Ethiopia

Por: Wubet · H. B. · Gobezie · N. Z. · Deress · G. M. · Mekuriaw · B. Y. · Abuhay · A. G. · Afework · W. A. · Siyoum · T. M. · Gedefaw · G. D. · Abate · A. T. · Demissie · B. · Demtie · D. G. · Asmare · T. B.
Objective

To assess how preoperative anaemia affects surgical outcomes in elderly patients within a resource-limited setting.

Design

Prospective cohort study.

Setting

Two comprehensive specialised hospitals in Ethiopia.

Participants

Participants consisted of 224 patients aged 65 years and older who underwent surgery between 1 December 2024 and 29 March 2025.

Primary and secondary outcome measures

Perioperative blood transfusions were the primary outcome. Secondary outcomes included intensive care unit (ICU) admission, risk of postoperative complications, prolonged hospitalisation, poor recovery quality and in-hospital mortality.

Results

The anaemic group required transfusions of three or more units more frequently than the non-anaemic group (10.5% vs 2.6%; absolute risk difference 8.0%). Their perioperative transfusion rates were significantly higher (42.3% vs 18.4%; p

Conclusion and recommendation

Preoperative anaemia significantly increases the risk of transfusion, poor recovery, ICU admission, prolonged hospitalisation and in-hospital mortality in older patients who underwent surgery. In resource-limited settings, improving perioperative outcomes should prioritise the early detection and treatment of anaemia.

Incidence and predictors of mortality among TB-HIV co-infected individuals on anti-tuberculosis and anti-retroviral dual therapy in Northwest Ethiopia: A retrospective cohort study

by Abebe Fenta, Tebelay Dilnessa, Destaw Kebede, Mekuriaw Belayneh, Zigale Hibstu Teffera, Bewket Mesganaw, Adane Adugna, Wubetu Yihunie Belay, Habtamu Belew, Desalegn Abebaw, Bantayehu Addis Tegegne, Zelalem Dejazmach, Fassikaw Kebede, Gashaw Azanaw Amare

Background

Co-infection with the human immunodeficiency virus (HIV) and tuberculosis (TB) is a primary cause of death and morbidity. The rate of morbidity and death from TB-HIV is still Ethiopia’s top health issue.

Objective

This study aimed to assess the incidence and predictors of mortality among TB-HIV co-infected individuals on anti-TB and anti-retroviral dual Therapy at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia.

Methods

A retrospective cohort study was conducted at the Debre Markos Comprehensive Specialized Hospital among 436 TB-HIV co-infected individuals. A computer-generated random sampling technique was used to select patient charts registered from September 1st, 2011, and August 31st, 2020. Epi-Data version 3.1 was used for data entry, and STATA version 13 was used for the analysis. The Kaplan-Meier survival curve was applied to estimate the cumulative survival time of the TB-HIV patients. Log-rank tests were utilized to compare the survival time across various categories of explanatory variables. Bi-variable and multivariable Cox proportional hazard models were fitted to find predictors of TB-HIV mortality.

Results

The mortality rate of TB-HIV co-infected individuals was 15.6%, with a median survival time of 42 months. Being male (Adjusted hazard Ratio (AHR)1.914;95%CI: 1.022–3.584), having CD4 count  Conclusion and recommendation

The mortality rate among TB-HIV co-infected patients at Debre Markos Comprehensive Specialized Hospital was high. Being male gender, having a CD4 count below 50 cells/mm³, being ambulatory and bedridden, having low baseline weight, and having low hemoglobin were the important predictors of mortality. To reduce mortality, it is crucial to focus on the early identification and management of high-risk patients, particularly those with low CD4 counts, poor functional status, and low hemoglobin. Strengthening integrated TB and HIV care services is recommended to improve patient survival outcomes.

Adverse pregnancy outcomes and associated factors among mothers who had operative vaginal delivery in Amhara Region Comprehensive Specialized Hospitals: multicentre cross-sectional study

Por: Misker · A. D. · Melesew · A. A. · Gobezie · N. Z. · Wubet · H. B. · Diress · G. M. · Abuhay · A. G. · Demite · D. G. · Tadesse · M. A. · Mihretie · G. N. · Abate · A. T. · Asmare · T. B. · Goshu · Y. A. · Siyoum · T. M. · Mekuriaw · B. Y. · Gedefaw · G. D. · Kebede · S. D. · Demissie
Objective

Assess the magnitude of adverse pregnancy outcomes and associated factors among mothers who had operative vaginal delivery in Amhara Region Comprehensive Specialized Hospitals, 2024.

Study design

A cross-sectional study was conducted from 1 November 2024 to 20 February 2025.

Study setting

Seven comprehensive specialised hospitals were included in the study.

Participants

The study was employed on 389 mothers who had operative vaginal delivery.

Methods

Systematic sampling was used. Data were collected via questionnaires, chart reviews and observation. Data were entered into Epi Data V.4.6 and analysed using V.25 statistical package of social sciences. Variables with p

Outcome

Adverse pregnancy outcomes of operative vaginal delivery.

Results

Adverse pregnancy outcomes of operative vaginal delivery were 42.2%. Among them, 46 (11.8%) had only maternal complications, 55 (14.1%) had only neonatal complications and 63 (16.2%) had both maternal and neonatal complications. Perineal tear 29 (7.5%) and episiotomy extension 31 (8%) were the most common maternal complications, while caput succedaneum 45 (11.6%) was the most neonatal complication. The most common indication of operative vaginal delivery was prolonged second stage 203 (52.2%). Vacuum-assisted delivery (AOR 0.53; 95% CI 0.29 to 0.96), two tractions (AOR 2.19; 95% CI 1.23 to 3.90), birth weight less than 2.5 kg (AOR 1.85; 95% CI 1.21 to 2.83) and mid fetal station (AOR 2.9; 95% CI 1.49 to 5.64) were significantly associated with adverse pregnancy outcomes.

Conclusions

Adverse pregnancy outcomes following operative vaginal delivery were high. Type of instrumental vaginal delivery, number of tractions, fetal birth weight and fetal station were significantly increased risks. Therefore, operators should minimise traction attempts during operative vaginal delivery to reduce adverse outcomes.

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