Conectar
Chronic prurigo is frequently complicated by chronic wounds and secondary bacterial infections, representing a major therapeutic challenge. A betulin-containing gel, approved for wound treatment in epidermolysis bullosa, has demonstrated wound-healing and antimicrobial properties beyond its licensed indication. To describe the clinical course of a chronic, recurrently superinfected wound in chronic prurigo treated with a betulin-containing topical gel. A 53-year-old male with chronic prurigo under systemic therapy with the Interleukin-4 and -13 antibody Dupilumab, presented with a persistent ulcerative lesion at the mandibular angle, repeatedly colonized by pathogenic bacteria despite prior systemic and topical antimicrobial therapy. Betulin-containing gel was applied twice daily under occlusion for 3 weeks. Clinical outcomes and microbiological findings were assessed. After 3 weeks of treatment, marked clinical improvement was observed, including reduced erythema and crusting, resolution of pain and itch, and complete epithelial stabilization. Follow-up wound swabs were negative for pathogenic bacteria. This case suggests that betulin-containing gel may represent a useful adjunctive treatment option for complex, superinfected chronic wounds in chronic prurigo. Further controlled studies are required to clarify its role in multimodal wound management.
Quality collaboratives improve quality of care at the hospital and collaborative levels, but less is understood about how such efforts affect patient-level disparities. This study evaluated how a quality improvement (QI) effort (increasing multiarterial grafting during coronary artery bypass grafting (CABG)) translated into populations which historically receive lower-quality care (females and patients of low socioeconomic status).
Retrospective cohort study.
All non-federal hospitals in the state of Michigan that perform cardiac surgery and participate in a statewide collaborative database (n=33).
Patients undergoing first-time, isolated CABG receiving at least two bypass grafts from 2011 to 2022 were identified.
Association of sex and socioeconomic status with multiarterial grafting was evaluated across the study period. The distressed community index (DCI), a socioeconomic ranking (0—not distressed, 100—severely distressed), was matched to the patient’s zip code. Hierarchical regression modelling was performed to associate DCI and sex with multiarterial grafting, incorporating patient factors and hospital and surgeon effects. A sex-surgery year and DCI-surgery year interaction term was performed to assess the change in the rate of multiarterial grafting.
A total of 40 322 patients underwent CABG at 33 centres with a median age of 66 years and 24% were female. The rate of multiarterial grafting was 15%, although lower among females (10% vs 17%) and the highest (vs lowest) DCI quartile (14% vs 18%). After risk adjustment, females were less likely to receive multiarterial grafting (ORadj 0.51 (95% CI 0.45 to 0.58), padj 0.35 per 10-point increase (95% CI 0.24 to 0.51), p0.05).
Despite a large overall increase in multiarterial grafting due to QI efforts, females and patients with low socioeconomic status had lower rates of multiarterial grafting. QI efforts should be evaluated both overall and among patients who historically receive lower quality care to improve quality and equity.
The study explored patient experiences of the Call for a Kit (CFAK) intervention, a community-based initiative designed to improve bowel cancer screening uptake and examined the mechanisms that may support participation among non-responders.
A convergent parallel mixed-methods design was employed, combining quantitative surveys and qualitative interviews.
The evaluation was conducted in general practices across Lancashire and South Cumbria, Northwest England, where CFAK clinics were delivered by an external health promotion team based within the Community Voluntary Services. These clinics target practices with low screening uptake.
A total of 113 CFAK attendees aged 54 and above, and who had missed their most recent screening invitation, completed a patient experience survey. 12 participants were purposively sampled for follow-up interviews.
Statistical analyses examined associations between patient experience and screening behaviours, including kit ordering and intention to complete the screening kit. Thematic analysis explored barriers and facilitators to participation, as well as experiences of CFAK clinics.
Patient experience scores were significantly higher among women than men and were positively associated with intention to complete the kit, though not with kit ordering. Qualitative findings indicated that CFAK addressed key barriers such as low awareness, confusion and emotional discomfort by providing personalised education, reassurance and culturally sensitive support. Participants particularly valued the relational aspects of the intervention, including the face-to-face delivery and communication in preferred languages.
CFAK clinics appear to enhance psychological capability and motivation for bowel screening by offering tailored, inclusive and supportive care. These findings highlight the value of patient-centred approaches in addressing inequalities in cancer screening and offer insights for the design of future community-based interventions.
by Xuying Zhang, Johanna Mainzer, Isabella Giambra, Tong Yin, Petra Engel, Hannah Hümmelchen, Henrik Wagner, Axel Wehrend, Christiane Egerer, Katharina Gerhards, Gerald Reiner, Sven König
Long tails trigger tail biting in pigs and increase the risk of flystrike infections in sheep. Tail docking has been a common management practice in both species for decades, but increasingly conflicts with legal animal welfare guidelines. Sustainable solutions require breeding strategies targeting shorter tails. In consequence, the aims were to conduct whole-genome sequencing (WGS)-based genome-wide association studies (GWAS) and comparative genomic analyses (CGA) to explore functional elements influencing tail traits. Phenotypically divergent experimental populations of pigs and sheep were established through unified selection and mating experiments. Tail traits included tail length (TL) measured at birth, and tail abnormalities (TA) assessed radiographically at 14 weeks of age. WGS-based GWAS identified a significant locus on SSC18 in pigs and suggestive loci for TL in both species, which, together with previously reported loci for TA, were further analyzed by CGA. The genomic windows of the significant locus on SSC18 in pigs and the TL GWAS locus on OAR4 in sheep were found to be conserved, harboring six common genes with predicted functional variants. These variants were jointly associated with TL (Plm ) in both species in linear regression models adjusted for sex, age of the dam, body length, and body weight. In other GWAS locus windows (±1 Mb), species-specific TL candidate genes were identified in sheep (HOXB13, MUC5B, EPB41L3, MTCL1, PIEZO2, MPPE1, and LOXHD1) and in pigs (KNL1, DISP2, SPRED1, TGFB2, and HAND1), each harboring associated putative functional variants. For TA, sheep-specific candidates (PGM2, LRRC66, CRACD, LOC105601916, and SH2D4B) and pig-specific candidates (MYOT, TMCO6, and PCDHAC2) were revealed using logistic regression models (Pglm ). GO analyses of candidate genes predicted shared biological processes between sheep and pigs, whereas pathway analyses indicated that common carbohydrate metabolism pathways, along with species-specific immune and inflammatory signaling, and pig-specific TGF-β signaling and endochondral ossification, may contribute to tail length variation and abnormalities. These findings provided deeper insights into the genetic basis of differential embryonic tail morphogenesis and perinatal tail development across species.Increasing evidence suggests that dolutegravir (DTG), endorsed by the WHO since 2018 for first-line antiretroviral therapy (ART), is associated with significant weight gain and potentially also with cardiometabolic disorders. In an effort to expand therapeutic options for people living with HIV (PLHIV), the EvaLuating the non-inferiority of DORAvirine vs DOlutegravir trial aims to compare the virologic efficacy of doravirine (DOR) and DTG-based regimens and to assess their safety, including a focus on cardiometabolic effects.
This is an international, phase III, multicentre, open-label, non-inferiority, randomised trial that will enrol 610 ART-naïve PLHIV (HIV RNA≥1000 copies/mL at screening) across six countries (Brazil, Cameroon, France, Côte d’Ivoire, Mozambique and Thailand) spanning four continents. Key inclusion criteria include age ≥18 years, confirmed HIV-1 infection with plasma RNA levels ≥1000 copies/mL, indication for ART initiation and no prior ART exposure. Participants will be randomised in a 1:1 ratio to receive either DOR 100 mg once daily in combination with tenofovir disoproxil fumarate (TDF) (300 mg daily) plus lamivudine (3TC) (300 mg daily) or DTG (50 mg daily) in combination with TDF (300 mg once daily) plus either emtricitabine (FTC) (200 mg daily) or 3TC (300 mg daily). Randomisation will be stratified by screening HIV-1 RNA load (≤100 000 or >100 000 copies/mL) and by country. The primary outcome is virological efficacy, defined as the proportion of participants achieving HIV-1 RNA
Primary outcome results (week 48) are expected in early 2028. The project was submitted to and approved by national ethics committees and pharmaceutical regulatory authorities in all participating countries: Brazil (CEP INI FIOCRUZ (21.040-900)/CEP HGNI (26.030-380)); Cameroon (CNERSH (2024/09/1717/CE/CNERSH/SP)/Ministry of Public Health (D30-1464/AAR/MINSANTE/SG/DROS/CRC); Côte d'Ivoire: (CNESVS (0018224/MSHPCMU/CNESVS-km)/AIRP (1329/AIRP/DISMP/Om/kbaag); France (CTIS CPP/ANSM (2023-508626-10-00)); Mozambique (CNBS (20/CNBS/25)/ANARME (4635/380/ANARME)); Thailand: (IHRP (08/1944)/Thai FDA: ongoing on 19 January 2026). The trial received authorisation from the French National Commission for Data Protection and Liberties (CNIL) under approval number 924 302. Written informed consent is obtained from all participants prior to any study-specific procedures and trial enrolment, in accordance with the Declaration of Helsinki and applicable national regulations. Study findings will be disseminated through publication in peer-reviewed journals and presentations at national and international scientific conferences. Results will also be communicated to policymakers, healthcare professionals, community stakeholders and study participants through appropriate dissemination activities, including policy briefs, stakeholder meetings and lay summaries on dedicated and easily accessible platforms.
NCT06203132; EU-CT, 2023-508626-10-00.
by Fezile Wagner, Unathi Kolanisi, Ryan G. Wagner, Lerato P. Makuapane, Mxolisi Masango, Francesc Xavier Gómez-Olivé
The COVID-19 pandemic exacerbated hunger levels in South Africa, with an increase from 10% pre-pandemic to 23% during the pandemic. Pre-pandemic national and global research identified university students to be more vulnerable to hunger compared to the general population. This elevated risk is commonly associated with prevalent financial mismanagement in this group. However, research investigating the prevalence of hunger during the pandemic among this at-risk group is limited. This cross-sectional study aimed to assess the prevalence and determinants of hunger among students at a South African university during the COVID-19 lockdown, with particular focus on the effect of returning home. An online, self-administered survey produced a sample of 596 students. The Household Hunger Scale (HHS) was used to assess hunger. Most students (84%) who resided in on- or off-campus residences before the lockdown returned home during the lockdown. The weighted prevalence of hunger during lockdown was 16.4% (95%CI 13.6%, 19.6%). Bivariate analyses found living alone to be significantly associated with hunger, while multivariate analyses found that first-generation students (adjusted odds ratio (aOR) = 1.78; 95%CI: 1.04, 3.07, p = 0.015), financial aid recipients (aOR = 2.69; 95%CI: 1.47, 4.91, p = 0.001), and those experiencing financial stress/worry (aOR = 3.38; 95%CI: 1.85, 6.18, pTo identify key communication skills for Canadian nursing practice.
Quantitative research using a nationwide survey.
Exploratory confirmatory factor analysis was used to identify factors underlying key communication skills required for nursing practice. Multiple regression analyses were used to examine differences across demographic variables, designations, roles and settings.
Dimensions of effective communication skills were identified. Demographic and contextual variables showed some impact on the perceived importance of communication skills, but low variance suggested that language demands are relatively consistent across roles and settings.
A framework describing the communication demands for Canadian nursing practice is described, contributing to the development of tailored curricula, assessments and policies.
Focusing on communication skills ensures that nurses are equipped to deliver safe healthcare and interact effectively with patients and colleagues, potentially leading to improved health outcomes.
To our knowledge, this study is the first to develop a framework for communication skills and identify key language skill factors across nursing professional designations and practice settings. The research provides a framework for developing curricula and training programmes that focus on essential communication skills.
No patient or public contribution.
While tuberculosis (TB) is associated with increased depressive symptoms, the long-term mental health trajectory post-diagnosis in low-resource settings remains poorly understood. This study investigated the longitudinal progression of depressive symptoms among individuals diagnosed with TB and evaluated whether symptom severity persisted or attenuated over time.
Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa. Population-based cohort study.
Rural Agincourt subdistrict, Mpumalanga province, South Africa, a high-TB-burden, resource-constrained region.
Adults aged 40 years and older who were permanent residents of the Agincourt subdistrict (N=5059 at baseline).
Depressive symptoms were assessed using the Centre for Epidemiologic Studies Depression Scale (CES-D) 8 (Wave 1) and CES-D 20 (Wave 2), with standardised scores enabling cross-wave comparisons. TB diagnosis status (self-reported) was categorised as recently diagnosed, previously diagnosed or never diagnosed.
At baseline, HIV prevalence was significantly higher (p
A recent TB diagnosis is strongly associated with depressive symptoms at baseline, and with the persistence of severe depressive symptoms 4 years later. These results were robust to a number of sensitivity tests and do not seem to be driven by differences in healthcare utilisation. Integrating mental health support into TB care programmes at all phases of diagnosis and treatment, particularly in low-resource settings, may have significant benefits.
To assess the prevalence of depression or depressive symptoms among engineering students.
Systematic review and meta-analysis of prevalence surveys using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
PubMed, Index Medicus Global, EMBASE, Web of Science, Scopus and PsycINFO were searched from 1 January 2003 to 28 June 2024.
Studies were included if they: (1) reported the prevalence of depression or depressive symptoms among engineering students, (2) used a validated instrument with defined cut-off points to assess depression or depressive symptoms and (3) were published in a peer-reviewed journal.
Two researchers independently extracted data using a standardised spreadsheet, collecting information on country of data collection, survey years, year of training, sample size, mean age of participants, number and percentage of male participants, assessment instrument, cut-off points and prevalence estimates. Discrepancies were resolved by a third researcher. Risk of bias was assessed with the Risk of Bias for Studies of the Prevalence of Mental Health Disorders tool. Prevalence estimates were synthesised using random-effects meta-analysis. Between-study heterogeneity was assessed with ² tests and the I² statistic. Subgroup analyses were conducted according to severity cut-off points, and meta-regression was used to explore the influence of study-level characteristics on prevalence estimates.
23 studies involving 12 758 students across 11 countries were analysed. All studies used validated scales with cut-off points to assess depression or depressive symptoms. The overall pooled prevalence was 42.6% (95% CI 32.7 to 53.1) for studies using symptom severity cut-off points at mild or above, and 33.1% (95% CI 25.2 to 42.0) for studies using symptom severity cut-off points at moderate or above. Meta-regression indicated a progressive annual increase in prevalence (OR 1.14, 95% CI 1.01 to 1.28, p=0.034) across studies conducted from 2014 to 2024.
Prevalence of depression and depressive symptoms is high among engineering students, at levels comparable to medical students. Given the substantial impact, further research should investigate risk factors and evaluate preventive, early detection and treatment strategies tailored to engineering students.
CRD42024571131.
The study focused on nurses' familiarity with, beliefs about, and attitudes towards artificial intelligence, aiming to identify configurations of necessary and sufficient conditions associated with strong intentions to use artificial intelligence-based health technologies in their clinical practice.
Cross-sectional survey conducted online from mid-October 2023 through early February 2024.
The fuzzy set qualitative comparative analysis method was employed to analyse the survey data.
307 members of the professional order of nurses in Québec province, Canada.
Findings from the qualitative comparative analysis show that strong intentions to use artificial intelligence are only observed when nurses perceive artificial intelligence to have a high impactfulness on their future clinical practice (necessary condition). Moreover, we observe three configurations of sufficient conditions, that is, three combinations (artificial intelligence profiles) of familiarity with, belief about, trust in, and perceived impactfulness of artificial intelligence.
Current curriculum efforts have centred on defining artificial intelligence competencies, yet competency alone does not guarantee a willingness to adopt artificial intelligence tools. Our findings indicate that a positive attitude towards artificial intelligence's potential impact is crucial, with various profiles supporting intentions to adopt artificial intelligence.
These findings suggest that nurses' preparation should go beyond developing artificial intelligence competencies and that nursing educators and trainers need to account for the different profiles associated with strong intentions to use artificial intelligence technologies. Training programmes and nursing curricula should prioritise shaping nurses' beliefs and attitudes about artificial intelligence rather than focusing solely on technical skills.
We contribute to nursing research by showing that a positive attitude towards artificial intelligence's impactfulness on nurses' future clinical practice is a necessary condition for having high intentions to use artificial intelligence technologies.
Relevant guidelines have been adhered to by employing recommended qualitative comparative analysis reporting methods.
No patient or public contribution.
The aim of this study is to identify and analyse research priorities across the osteopathic profession internationally, to determine how different interested parties conceptualise research importance and to examine how contextual factors influence research prioritisation.
A mixed methods sequential exploratory design combining an umbrella review, a thematic analysis, an expert consensus agreement and an international cross-sectional survey was used to define, validate and evaluate research priorities.
An international online survey, available in nine languages, was distributed through professional osteopathic organisations and network worldwide, a patient representative organisation and social media.
2229 respondents including patients (7.4%), practitioners (42.1%), students (17.4%), educators (13.5%), researchers (5.0%) and policy makers (4.3%) from across 42 countries.
Primary outcomes were interested party’s conceptualisation of research importance and validation of the priorities in Research for Osteopathic Care (PROCare) framework. Secondary outcomes included current research priorities across interested parties groups and influence of contextual factors on prioritisation.
Three distinct approaches to priority-setting emerged: conservative (42.9%), sceptic (20.2%) and enthusiast (36.9%). Organising research priorities as a construct built from domains and subdomains was shown to be internally valid (Cronbach’s α=0.911). ‘Patient safety’ (nominated by 82% of relevant countries) and ‘physical activities and mobility’ (51.0%) were the most prioritised subdomains. ‘Digital health’ ranked lowest (28th of 28 subdomains). Significant geographic variations were observed mainly for the overall importance to most research domains. Strong consensus emerged around core priorities including patient safety, physical activity promotion and understanding treatment mechanisms.
The PROCare framework provides a validated structure for evaluating osteopathic research priorities across diverse interested parties. While geographic variations exist in priority emphasis, fundamental agreement on key research domains suggests potential for internationally coordinated research strategies. Future work should focus on developing mechanisms to ensure balanced representation of conservative, sceptic and enthusiast perspectives in research planning.
To investigate the occurrence of depression and mental health disorders other than depression among Brazilian people with intellectual disabilities, analysing data from a national household survey.
Cross-sectional epidemiological study using data from the 2019 National Health Survey (PNS).
Brazil, nationwide data collection in urban and rural private households.
272 499 individuals, among whom 1.2% (n=3198) reported intellectual disabilities.
Self-reported depression and mental health disorders other than depression (anxiety, panic, schizophrenia, bipolar disorder, psychosis or obsessive–compulsive disorder (OCD)), either isolated or comorbid.
Among people with intellectual disabilities, 43.2% reported at least one mental health disorder versus 13.7% without disabilities. In adults aged 0–59 years, intellectual disability was associated with higher odds of depression (adjusted OR (aOR) 3.25, 95% CI 1.76 to 6.00), mental health disorders other than depression (aOR 12.23, 95% CI 7.52 to 19.90) and depression associated with other mental health disorders (aOR 14.34, 95% CI 7.92 to 25.96). In older adults (≥60 years), risks also remained elevated: depression (aOR 1.71, 95% CI 1.04 to 2.79), mental health disorders other than depression (aOR 4.33, 95% CI 2.09 to 8.94) and depression associated with other mental health disorders (aOR 2.98, 95% CI 1.49 to 5.95). Women with intellectual disabilities were more likely to report depression and multimorbidity, while men more often reported non-depressive disorders. Poorer self-perceived health was consistently linked to worse outcomes across age groups.
Mental health disorders and their comorbidities are significantly more prevalent among people with intellectual disabilities in Brazil. These findings highlight the urgent need for inclusive, equitable and specialised mental healthcare policies.
Nurses confront substantial daily workloads. Coping mechanisms, including resilient behaviours at both individual and team levels, are pivotal in managing these challenges. Factors like work experience can significantly influence individual resilience. Yet, team resilience among nurses remains relatively unexplored.
Our study examined perceptions of both individual and team resilience among Dutch hospital nurses. Furthermore, we investigated the impacts of hospital type, ward type and work experience.
The Employee Resilience Scale was used to evaluate individual resilience and adapted for team contexts to assess team resilience. This study was one of three conducted under a governmental research program aimed at improving patient safety in the Netherlands. A paired t-test and correlation analysis were conducted to compare individual resilience with team resilience. A separate t-test assessed the impact of ward type on perceived individual and team resilience. Finally, post hoc analyses were used to examine the effects of hospital type and work experience.
In total, 344 nurses from 25 different wards of 17 Dutch hospitals completed the survey. In general, nurses indicated to act more resilient on the individual level (mean = 3.77, SD = 0.61) compared to the team level (mean = 3.53, SD = 0.65; t = 7.25, p = 0.00). A correlation was found between perceived individual and team resilience (r = 0.53, p = 0.00). No effects of hospital- and ward type were found on both individual or team resilience. Years of work experience did not affect individual resilience but showed a significant effect on team resilience.
Dutch hospital nurses indicated they often act resilient on both individual and team levels. However, with increasing workloads in healthcare, being able to remain resilient will become increasingly challenging and important. Organisations should therefore support employees to maintain resilience by adapting their work environment to meet more employees' needs.
To investigate whether quantitative retinal markers, derived from multimodal retinal imaging, are associated with increased risk of mortality among individuals with proliferative diabetic retinopathy (PDR), the most severe form of diabetic retinopathy.
Longitudinal retrospective cohort analysis.
This study was nested within the AlzEye cohort, which links longitudinal multimodal retinal imaging data routinely collected from a large tertiary ophthalmic institution in London, UK, with nationally held hospital admissions data across England.
A total of 675 individuals (1129 eyes) with PDR were included from the AlzEye cohort. Participants were aged ≥40 years (mean age 57.3 years, SD 10.3), and 410 (60.7%) were male.
The primary outcome was all-cause mortality. Quantitative retinal markers were derived from fundus photographs and optical coherence tomography using AutoMorph and Topcon Advanced Boundary Segmentation, respectively. We used unadjusted and adjusted Cox-proportional hazards models to estimate hazard ratios (HR) for the association between retinal features and time to death.
After adjusting for sociodemographic factors, each 1-SD decrease in arterial fractal dimension (HR: 1.54, 95% CI: 1.18 to 2.04), arterial vessel density (HR: 1.59, 95% CI: 1.15 to 2.17), arterial average width (HR: 1.35, 95% CI: 1.02 to 1.79), central retinal arteriolar equivalent (HR: 1.39, 95% CI: 1.05 to 1.82) and ganglion cell-inner plexiform layer (GC-IPL) thickness (HR: 1.61, 95% CI: 1.03 to 2.50) was associated with increased mortality risk. When also adjusting for hypertension, arterial fractal dimension (HR: 1.45, 95% CI: 1.08 to 1.92), arterial vessel density (HR: 1.47, 95% CI: 1.05 to 2.08) and GC-IPL thickness (HR: 1.56, 95% CI: 1.03 to 2.38) remained significantly associated with mortality.
Several quantitative retinal markers, relating to both microvascular morphology and retinal neural thickness, are associated with increased mortality among individuals with PDR. The role of retinal imaging in identifying those individuals with PDR most at risk of imminent life-threatening sequelae warrants further investigation.
FreshRSS 