Conectar
Drug poisoning, caused predominantly by fentanyl in the unregulated drug supply, is the leading cause of death among persons 10–59 years in British Columbia (BC), Canada. In March 2020, in response to the emergence of the COVID-19 pandemic, the province of BC released the Risk Mitigation Guidance (RMG) as a clinical tool for physicians and nurse practitioners, allowing prescribers to provide selective withdrawal management medications, such as hydromorphone, dextroamphetamine, diazepam and others, as a legal and regulated supply of pharmaceutical alternatives to individuals who were at-risk of COVID-19 and overdose. In July 2021, the government of BC released the prescribed safer supply (PSS) policy, extending the scope beyond the COVID-19 pandemic and initial medications offered under the RMG. Recent studies have shown clear benefits among people with a diagnosed opioid use disorder who were prescribed PSS, in reducing mortality, as well as improving retention on opioid agonist treatment for those who were coprescribed PSS medications. The objective of the analysis detailed in this protocol is to use a cross-model comparison approach, comparing two independently developed models which are currently used in public health institutions in BC, to estimate the impact of this policy on opioid overdose-related mortality, while also considering the potential negative impacts of PSS medication diversion to those who are opioid naïve. This project will add to the limited evidence-base on the population-level impact of pharmaceutical alternatives interventions to date.
We have identified two appropriate mathematical models to evaluate the impact of PSS on the number of opioid overdose-related deaths within BC from the inception of the programme (March 2020) until December 2022. We will use recently established guidelines on conducting a cross-model comparison to identify structural and parameter differences between the models and perform adaptation steps to generate the counterfactual scenarios. These will include creating additional health states for the population representing individuals receiving PSS, and parameterising the overdose risk, mortality and retention in the new compartments from a comprehensive population-level data set. Harmonisation will be conducted to ensure that both models evaluate the same scenarios with the same data. Further sensitivity analyses will be conducted to consider alternative counterfactual scenarios and changes to the population following the implementation of the intervention.
This study is exempt from research ethics board review, as outlined in the Tri-Council Policy Statement, because it relies on data that is available in the public domain and there is no possibility of identifying individual persons. Results of the model validation analysis will be distributed through peer-reviewed journals and knowledge translation materials posted on the websites of the BC Centre for Disease Control and Centre for Advancing Health Outcomes.
To explore parents’ experiences of parenting adolescents with food allergies.
An interpretive descriptive qualitative study.
Semi-structured interviews were conducted between November 2023 and March 2024 with 11 parents of adolescents with food allergies aged 12–16 years, 8 mothers and 3 fathers. Reflexive thematic analysis was conducted.
Three themes were generated: (1) Impact on everyday life, which concerns having to ‘always be on alert’, restriction as a family and mitigating feelings of difference in their child, (2) ‘handing over the reins,’ which describes parents role in the process of transition, including trusting their child, considering new adolescent socialising behaviours such as alcohol and intimate relationships, and ‘letting go' of some responsibility, and (3) learning, which details common misconceptions that parents still have and lessons learned from experiences of anaphylaxis and from tragedies in the media.
This study adds substantial knowledge about the parental experience in food allergy, specific to parents of adolescents. Parents endure constant worry for their child, heightened at critical times, including the transition period of adolescence. Parents need guidance and support from healthcare professionals in this crucial time of change. Further education is needed as knowledge gaps remain even at this advanced stage in a parent's food allergy journey. Throughout the narrative, there was an undercurrent of parental anxiety, with periods of heightened anxiety illustrated in each theme.
The topic of transition and parents' role in the process should be introduced by healthcare professionals. Future work should focus on creating learning resources for families which cover the common areas of concern identified. Accessible education is needed for healthcare professionals without a background in allergy, particularly concerning anaphylaxis management.
The Reflexive Thematic Analysis Reporting Guidelines were used to guide reporting.
No Patient or Public Contribution.
To identify the proportion of Advanced Practice Nurses' workload that takes place virtually in the delivery of direct patient care.
An observational study was conducted for this research.
An overt non-participatory time and motion study was undertaken using a predefined data collection tool to identify the activities of the study participants, and the mode used for delivery of the activities identified.
Fourteen Advanced Practice Nurses were observed. A total of 5190 min of observation time was conducted. The time participants were observed delivering direct patient care virtually (care delivered without in-person contact) was recorded in minutes and calculated as a percentage of their overall observation time. The proportion of time recorded in the delivery of virtual direct patient care was calculated as 22% of participants' work time. The primary modes of telecommunication technologies used in this research were landline telephones and desktop computers. The most frequently performed direct patient care activity was gathering and interpreting assessment data to formulate a plan of care.
This is the first research to calculate the proportion of Advanced Practice Nurses' time that is spent delivering direct patient care virtually. The findings indicate that a substantial proportion of Advanced Practice Nurse time is spent delivering virtual care.
No patient or public contribution in this research.
Implications for the profession and/or patient care.
What problem did the study address? There is an increase in the digitalisation of healthcare delivery, resulting in virtual care provided by nurses. It is therefore important to explore what and how much virtual care is delivered by Advanced Practice Nurses in Ireland. The study calculated the proportion of Advanced Practice Nurses' time spent in the delivery of virtual direct patient care. What were the main findings? A significant volume of work is conducted virtually. It should be conducted in a secure environment using secure devices. The nurses conducting virtual direct patient care ought to be adequately resourced with appropriate technology supported by electronic recording of care delivered to ensure accurate communication between healthcare professionals. Education for nurses conducting virtual work should be provided from the outset. Where and on whom will the research have an impact? The research will impact nurse leaders by providing them evidence of the delivery of virtual direct patient care by nurses. This leads to an opportunity to explore funding models where direct patient care is delivered yet unseen. There is a requirement to provide nurses with the necessary equipment to support the delivery of virtual patient care. Further research is recommended on the virtual role of nurses in healthcare delivery.
The STROBE cross-sectional guidelines were followed to report the research.
To summarise current research that defines cardiopulmonary resuscitation and to provide a succinct conceptual definition of cardiopulmonary resuscitation.
Scoping review using JBI guidelines to develop the study protocol.
The most recent (2024) research papers on cardiopulmonary resuscitation were evaluated for inclusion. Individual definitions of cardiopulmonary resuscitation extracted from 25 papers were summarised and then analysed to conceptualise a single definition for cardiopulmonary resuscitation.
CINAHL, Medline and Scopus databases were evaluated for inclusion.
Definitions of cardiopulmonary resuscitation focused on interventions, mainly chest compressions and ventilation. Defibrillation was inconsistently included. There was less emphasis on criteria for initiating cardiopulmonary resuscitation and desired outcomes.
This scoping review found limited consensus between definitions of cardiopulmonary resuscitation. Analysis of the range of perspectives found in the review enabled the researchers to propose definitions in three areas: cardiopulmonary resuscitation, basic life support and advanced life support.
Nurses working in hospitals and responding to cardiac arrests are guided by Advanced Resuscitation Plans and Do Not Resuscitate orders. In turn, these documents should communicate a clear definition of cardiopulmonary resuscitation in policies, procedures and standards. This is important for clinical nurses to ensure patients' consent for cardiopulmonary resuscitation and defibrillation is informed.
Currently cardiopulmonary resuscitation is inconsistently defined. Cardiopulmonary resuscitation includes compressions and ventilation. A standardised definition of cardiopulmonary resuscitation supports professional nursing practice and has wider implications for patient consent and research practice.
This scoping review adheres to and is reported according to PRISMA-ScR.
No patient or public contribution.
To explore the challenges experienced by people with intellectual disability, their carers and health and social care professionals when using and managing medication.
A synthesis of qualitative research using meta-ethnography.
We searched seven databases: MEDLINE, Embase, CINAHL, Science, Social Science and Conference Proceedings Citation Indices (Web of Science), Cochrane Library, PsycINFO and Proquest Dissertations and Theses from inception to September 2022 (updated in July 2023).
We included studies exploring the challenges and perceptions of people with intellectual disability, their carers and health and social care professionals regarding medication management and use.
We reviewed 7593 abstracts and 475 full texts, resulting in 45 included papers. Four major themes were identified: (1) Medication-related issues, (2) navigating autonomy and relationships, (3) knowledge and training needs and (4) inequalities in the healthcare system. We formulated a conceptual framework centred around people with intellectual disability and described the interconnectedness between them, their carers and health and social care professionals in the process of managing and using medication. We identified challenges that could be associated with the person, the medication and/or the context, along with a lack of understanding of these challenges and a lack of capability or resources to tackle them. We developed an overarching concept of ‘collective collaboration’ as a potential solution to prevent or mitigate problems related to medication use in people with intellectual disability.
The effective management of medication for people with intellectual disability requires a collaborative and holistic approach. By fostering person-centred care and shared decision-making, providing educational and practical support, and nurturing strong relationships between all partners involved to form a collective collaboration surrounding people with intellectual disability, improved medication adherence and optimised therapeutic outcomes can be achieved.
CRD42022362903.
Background
Chronic pain is a major cause of distress and disability, and biomarkers may aid in the assessment and treatment of it. Urine metabolites may be valuable bioindicators that can provide biological insight regarding chronic pain.
Objectives
To investigate the relationship between a multimarker composite measure of metabolites and patient-reported outcomes scores in adults with chronic pain, using data from a pragmatic clinical trial with a sequential, multiple-assignment randomized trial design.
Methods
Self-reported measures and urine samples from 169 active-duty service members with chronic pain were collected. Urine was analyzed using a preestablished panel of metabolites, including four previously identified biomarkers of pain: kynurenic acid, pyroglutamic acid, ethylmalonic acid, and methylmalonate. Multivariable linear regression models—adjusted for participant characteristics such as age and sex—were used to cross-sectionally examine the relationship between 11 patient-reported outcomes (fatigue, sleep-related impairment, anxiety, depression, anger, pain catastrophizing, physical function, pain interference, satisfaction with participation with social roles, pain intensity, and pain impact score) and the four urine metabolites both individually and as a composite (urine metabolite pain indicator, or UMPI). Given the study’s small sample size and exploratory nature, a significance threshold of p ≤ .10 was used for all analyses.
Results
The UMPI showed statistically significant associations with five self-reported measures (fatigue, anxiety, depression, physical functioning, and pain impact score); adjusted Pearson correlations ranged from .18 to .25. Individual metabolite analyses supported these findings, with all relationships between individual metabolites and self-reported measures showing positive associations. Kynurenic acid and ethylmalonic acid showed the strongest associations, each having statistically significant relationships with four individual self-reported measures, while pyroglutamic acid had statistically significant relationships with three self-reported measures and methylmalonate with none. The UMPI demonstrated feasible reliability.
Discussion
Our finding of associations between the UMPI and components of the self-reported measures supports the development of the UMPI and these four urine metabolites as biomarkers for chronic pain outcomes. Further research is planned and will be essential for establishing mechanistic insight and guiding biomarker development within the context of pain management. 
FreshRSS 