Conectar
by Ugur Yilmaz, Huseyin Celik, Pinar Arpinar-Avsar
This study examined how time pressure influences lower-limb biomechanics during single-leg maximal countermovement jumps (CMJs), with a focus on kinetic and kinematic responses during both jumping and landing phases. Participants performed single-leg CMJs under two conditions: self-paced (SP) and reaction-time (RT), the latter simulating time-constrained environments. Joint angles, ground reaction forces (vGRF), and joint moments were analyzed. Significant differences emerged between SP and RT tasks in jumping-phase kinetics and kinematics, with only kinematic differences present during landing. The RT condition led to reduced hip and knee flexion, increased peak vGRF, and shorter flight times, yet no improvement in jump height. This suggests inefficient energy transfer possibly due to reduced range of motion and increased muscle co-contraction or pretension strategies. Joint moment analysis revealed a shift from a hip-dominant strategy in SP to a knee-dominant strategy in RT. Landing in RT was characterized by reduced joint flexion and increased frontal plane loading, potentially elevating the risk of lower-limb injury. Time pressure modifies motor strategies in single-leg CMJs, promoting faster execution at the cost of performance efficiency. These findings underscore the importance of training for both explosive performance and neuromuscular control under time-constrained, sport-specific conditions.by Wenshu Li, Jeffrey A. Leibowitz, Shuoguo Wang, Louisa Walker, Chang Xu, Kuei-Ting Chen, Alexa B. Schrock, Jason Hughes, Nimesh Patel, Julia A. Elvin, Lauren L. Ritterhouse, Ethan Sokol, Garrett Frampton, Lucas Dennis, Bahar Yilmazel, Brennan Decker
Homologous recombination repair (HRR) is a cellular pathway for high-fidelity double strand DNA break repair that uses the sister chromatid as a guide to ensure chromosomal integrity and cell viability. Deficiency in the HRR pathway (HRD) can sensitize tumors to poly (ADP-ribose) polymerase inhibitors (PARPi) and platinum-based chemotherapy, offering an avenue to identify patients who may benefit from targeted therapies. HRD signature (HRDsig) is a pan-solid-tumor biomarker on the FoundationOne®CDx (F1CDx®) assay that employs a DNA scar-based approach to calculate a score based on copy number features (e.g., segment size, oscillation patterns, and breakpoints per chromosome arm) and does not rely on HRR gene alterations, enabling detection of genomic and epigenetic mechanisms of HRD. After finalizing the HRDsig algorithm, analytical validation was conducted in a CAP-accredited, CLIA-certified laboratory on 278 solid tumor and normal tissue specimens. HRDsig results were compared with an independent HRD biomarker, defined by the presence of a reversion mutation restoring HRR gene function. In this evaluation, 100 HRD-positive and 126 HRD-negative samples showed a positive percent agreement of 90.00% and a negative percent agreement of 94.44%. The limit of detection (LoD) was estimated at 23.04% tumor purity, with the limit of blank (LoB) confirmed as zero in 60 normal tissue replicates. Reproducibility testing on 11 positive and 11 negative samples across multiple labs, reagent lots, and sequencers yielded agreement in 99.49% of positive and 99.73% of negative replicates. HRDsig status remained consistent in the presence of interfering substances, demonstrating 100% concordance in spiked samples. These validation results underscore the high analytical concordance, low false-positive rate, and overall robustness of HRDsig for reliable assessment of homologous recombination deficiency.Children with special needs frequently experience accidents and injuries due to motor control difficulties. The most common home accidents include falls, burns, poisoning, drowning and choking. Compared to their typically developing peers, children with special needs are at a higher risk of home accidents and emergency department visits. Falls related to balance impairments are especially common in this population. The aim of this study is to assess the effects of a virtual reality-based home accident control simulation combined with first aid training on the awareness and initial responses to home accidents of parents of children with special needs, using a single-group pre-post quasi-experimental design.
This quasi-experimental study, using a pre-test/post-test design, is planned to include 100 volunteer parents of children with special needs who are registered at a Barrier-Free Life Application and Research Centre. The parents will receive training on home accidents via virtual reality simulation, supplemented by first aid and transfer training. Data will be collected using the Descriptive Information Form and the Home Accident Awareness Questionnaire for Parents of Children with Special Needs. Children’s balance status will be assessed to determine their fall risk using the Children’s Balance Assessment Form, the Tinetti Balance and Gait Assessment and the Nintendo Wii Fit Balance Board.
Ethical approval was obtained from the Ethics Committee of Istanbul Topkapi University. The results will be disseminated through peer-reviewed journals and academic conferences.
NCT06839196 (ClinicalTrials.gov). Protocol version: 1.2; Protocol Date: 30 April 2025. All items from the WHO Trial Registration Data Set are available in the registry record.
This study aimed to explore nurses' experiences with the Braden Scale, assess their readiness for artificial intelligence (AI) technologies, and understand the innovations they envision for clinical practice.
Explanatory sequential mixed design.
The study included 118 nurses in the quantitative data and 42 in focus groups. Quantitative data were collected using the MAIRS-MS. Qualitative data were analysed using phenomenological approaches and MAXQDA.
The average age was 33.38 ± 7.42 years and 88.1% were women. The average length of professional experience is 11.66 ± 8.22 years. The average time to administer the Braden Scale was 5.02 ± 4.36 min. While 55.1% of the participants found the Braden Scale inadequate, 55.9% stated that a more comprehensive risk assessment scale was needed and the MAIRS-MS score was 78.48 ± 16.66. The sub-themes were identified: Simple and quick applicability, early risk identification, validity and reliability issues, neglecting other risk factors, making it more comprehensive and specific, developing of a new risk assessment scale, technological improvements, patient data treasure chest, creating avatars and converting speech-to-text.
This study highlights critical gaps in the Braden Scale's effectiveness. Nurses identified significant shortcomings, including non-specificity and the neglect of key risk factors, which undermine its utility in clinical settings. They emphasised that stronger risk predictions and personalised care plans can be achieved by AI technology.
This study emphasises the need to revise the Braden Scale or develop a new one due to its limitations in risk assessment, providing crucial information to improve patient care and offering new perspectives on AI integration in PI risk assessment for nursing practice.
This study highlights nurses' experiences and suggestions for improving the Braden Scale in clinical practice, emphasising their expectations for AI technology and its potential to revolutionise patient care.
The study report was prepared following the Good Reporting of A Mixed Methods Study (GRAMMS) checklist.
No patient or public contribution.
The aim of this study was to investigate the effect of postoperative thirst on patient comfort and quality of recovery in patients undergoing colorectal surgery.
This study is an analytical cross-sectional study.
This study was conducted between July 2022 and January 2023 in the general surgery clinics of a university hospital in Ankara, Türkiye. The study sample consisted of 110 patients. Patient Identification Form, Thirst Symptom Assessment Scale (TSAS), Numeric Rating Scale (NRS), Perianesthesia Comfort Scale (PCS) and Quality of Recovery-40 questionnaire (QoR-40) were used for data collection. The severity of thirst was assessed three times: at the time of arrival to the postoperative clinic, at the 8th hour, and at the 24th hour, and the PCS and QoR-40 scales were administered at the 24th hour.
In this study, more than half of the patients were male (62.7%) and the mean age was 61.35 ± 13.79 years. The mean thirst severity of the patients was 12.25 ± 4.65, 12.36 ± 4.49 and 11.27 ± 4.76 according to the TSAS, 7.27 ± 2.39, 7.27 ± 2.01 and 6.17 ± 2.89 according to the NRS, respectively. The mean total score of PCS was 5.12 ± 0.43 and the mean total score of QoR-40 was 171.58 ± 10.33. Postoperative 8th hour thirst severity according to NRS, PCS total score level and postoperative thirst severity measured by TSAS at three times were found to have a significant effect on QoR-40 total score level in a decreasing direction. PCS total score was found to have a significant effect on QoR-40 total score level in an increasing direction.
The results obtained in this study showed that the thirst symptom experienced by the patients was moderate. It was determined that an increase in the severity of thirst decreased patients' comfort and quality of recovery levels, whereas an increase in comfort level increased the level of quality of recovery.
It is recommended that the severity of thirst should be assessed frequently with appropriate scales and appropriate nursing care should be provided for thirst management in order to increase the postoperative comfort of patients and to improve their recovery more positively.
No study has been found to describe and compare the effect of postoperative thirst on comfort and quality of recovery in patients undergoing colorectal surgery. In this study, it was found that an increase in the severity of postoperative thirst decreased the level of postoperative comfort and quality of recovery, whereas an increase in the level of postoperative comfort increased the level of quality of recovery. This information can be used to optimally manage the symptom of thirst after colorectal surgery, develop evidence-based nursing interventions, and improve the quality of care.
This study was reported according to the STROBE checklist.
Patients answered the scales with their voluntary consent. There is no public contribution.
To examine the factors affecting the ability of ostomates to perform activities of daily living and manage ostomy self-care.
Mix method design.
This study was undertaken through survey (descriptive and clinical characteristics form and Katz Activities of Daily Living (ADL)) for collecting the quantitative data (n = 60) and semi-structured interviews were conducted with patients unable to perform ostomy self-care for collecting qualitative data (n = 12) between January 2023 and December 2023.
Factors hindering the ability to perform ostomy self-care were physical reasons (68.3%) and psychological reasons (66.7%). Multiple linear regression analysis revealed that individuals with a chronic disease have a Katz ADL score 12.6 times higher than those without a chronic disease (p = 0.004, OR = 12.665, 95% CI: 2.304–69.614). Qualitative analysis identified three themes as challenges, taking over ostomy care and factors improving the quality of life with ostomy.
The findings indicate that having an ostomy impairs individuals' ability to perform daily activities independently and manage their ostomy. Additionally, the presence of a chronic disease in ostomates predicts greater dependence in daily activities. In this regard, support mechanisms should be identified and activated based on the needs of ostomates and chronic diseases, with nursing interventions tailored to address those needs.
A dedicated team of specialised ostomy nurses can offer valuable support by focusing on ostomy management and assessing factors that affect both self-care and daily activities.
This study highlights the impact of coping with an ostomy on daily life and self-care, underscoring the need for targeted support for vulnerable groups and guiding ostomy care nurses in post-discharge follow-up and support group organisation.
STROBE and GRAMMS checklists.
Patients contributed to the study by sharing their experiences through face-to-face interviews during data collection process.
To determine the incidence of pressure injuries from medical devices in children.
Medical devices can cause pressure injuries on skin and soft tissues.
A prospective, descriptive study adhering to STROBE guidelines.
This study was conducted in the third-level Paediatric Intensive Care Unit of Ege University Hospital in İzmir, Türkiye between April 2019 and October 2019 in Türkiye. Patients aged between 1 month and 18 years with medical devices were observed for pressure injuries using Braden scales and a specific monitoring form.
In this study, we followed 522 medical devices applied to 96 patients. The three most commonly used medical devices were the ECG probe (21%), the blood pressure cuff (16%) and the saturation probe. Out of the 522 medical devices followed, 36 caused pressure injuries (6.8%).
The incidence of medical device-related pressure injuries was found to be high. Effective training and implementation strategies need to be devised for paediatric nurses to prevent pressure injuries associated with medical devices.
The results of this study reveal that pressure injuries related to medical devices are an important health problem in paediatric hospitals. Therefore, awareness-raising and educational activities among health professionals and nurses should be accelerated.
No patient or public contribution in the study.
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