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Onion extract gel is not better than other topical treatments in scar management: A meta‐analysis from randomised controlled trails

Abstract

To evaluate the efficacy and safety of onion extract (OE) gel on scar management, a systematic review was performed by searching Embase, PubMed, Medline, and the Cochrane Library databases, and a meta‐analysis was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement guidelines. Finally, 13 randomised controlled trails were enrolled for meta‐analysis. OE gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P < .00001) than no treatment, but no differences were detected between OE gel and other commonly used topical treatments assessed by investigators (P = .56) and patients (P = .39). Moreover, OE in silicone gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P = .0007) than other treatments. OE gel increased the incidence of total adverse effects compared with no treatment (P < .0001) and other treatments (P = .008) by a fixed‐effects model, and increased the incidence of dropping out caused by intolerance of treatments (P = .0002). OE gel not only has no superiority to commonly used topical treatments, but also has the potential to increase the incidence of adverse effects on scar management; OE in silicone gel might be the optimal topical choice for scar treatment; however, more evidences are needed to strength these conclusions.

Onion extract gel is not better than other topical treatments in scar management: A meta‐analysis from randomised controlled trails

Abstract

To evaluate the efficacy and safety of onion extract (OE) gel on scar management, a systematic review was performed by searching Embase, PubMed, Medline, and the Cochrane Library databases, and a meta‐analysis was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement guidelines. Finally, 13 randomised controlled trails were enrolled for meta‐analysis. OE gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P < .00001) than no treatment, but no differences were detected between OE gel and other commonly used topical treatments assessed by investigators (P = .56) and patients (P = .39). Moreover, OE in silicone gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P = .0007) than other treatments. OE gel increased the incidence of total adverse effects compared with no treatment (P < .0001) and other treatments (P = .008) by a fixed‐effects model, and increased the incidence of dropping out caused by intolerance of treatments (P = .0002). OE gel not only has no superiority to commonly used topical treatments, but also has the potential to increase the incidence of adverse effects on scar management; OE in silicone gel might be the optimal topical choice for scar treatment; however, more evidences are needed to strength these conclusions.

Effect of humour intervention programme on depression, anxiety, subjective well‐being, cognitive function and sleep quality in Chinese nursing home residents 幽默干预对中国养老院老人的抑郁、焦虑、主观幸福感、认知功能和睡

Abstract

Aim

To evaluate the effect of an 8‐week humour intervention programme on reducing depression and anxiety and improving subjective well‐being, cognitive function and sleep quality in nursing home residents.

Design

A single‐blinded and quasi‐experimental design with repeated measures.

Methods

Seventy‐four older adults were recruited from May 2018–September 2018, with 37 older adults in the humour group received humour intervention and 37 in the control group received no intervention. The intervention was an 8‐week humour intervention programme for older adults to learn to use humour and release their emotions. Primary outcomes include depression, anxiety and subjective well‐being and secondary outcomes were cognitive function and sleep quality. Two‐way repeated measures ANOVA was used to compare the differences of outcome measures between the two groups. Outcomes were measured at baseline, 8 and 16 weeks.

Results

There was no significant difference between the two groups at baseline. The adherence to the sessions of humour intervention over the 8‐weeks was 97.6%.

Two‐way repeated measures ANOVA revealed significant improvement in depression, anxiety, subjective well‐being and sleep quality during the postintervention (8 weeks) and follow‐up (16 weeks) periods in the humour group versus the control group. However, a significant time × group interaction for cognitive function was only found during postintervention.

Conclusion

The humour intervention programme was effective in reducing depression and anxiety symptoms and increasing subjective well‐being, cognitive function and sleep quality in older adults.

Impact

Physical and mental health problems are common among older adults in nursing homes. The study demonstrated that humour intervention has feasibility and potential to be used as an effective non‐pharmacological intervention in improving well‐beings of Chinese nursing home residents.

Trial Registration

ChiCTR1800016148.

目标

为了评估为期8周的幽默干预计划对减少疗养院老人的抑郁、焦虑、主观幸福感、认知功能和睡眠质量的影响。

设计

重复测量的单盲准实验设计。

方法

从2018年5月至2018年9月,共招募74位老年人,其中幽默组的37位老年人接受了幽默干预,对照组的37位未接受干预。这项干预是一项为期8周的幽默干预计划,旨在让老年人学习使用幽默并释放情绪。主要结果包括抑郁、焦虑和主观幸福感,次要结果包括认知功能和睡眠质量。采用双向重复测量方差分析比较两组结果的指标差异。在基线、第8周和16周测量结果。

结果

基线时两组没有显著差异。在8周内,参加幽默干预的比例为97.6%。双向重复测量的方差分析显示,与对照组相比,幽默组在干预后(8周)和随访(16周)期间,抑郁、焦虑、主观幸福感和睡眠质量显著改善。但是,仅在干预后才发现认知功能有显著的时间×群体交互作用。

结论

幽默干预计划可以有效减少老年人的抑郁和焦虑症状,提高主观幸福感、认知功能和睡眠质量。

影响

在养老院中,老年人身体和心理健康问题十分普遍。研究表明,幽默干预具有可行性和潜力,可以用作改善中国养老院老人幸福感的有效非药物干预手段。

试验注册

ChiCTR1800016148。

ALK inhibitors for non-small cell lung cancer: A systematic review and network meta-analysis

by Jesse Elliott, Zemin Bai, Shu-Ching Hsieh, Shannon E. Kelly, Li Chen, Becky Skidmore, Said Yousef, Carine Zheng, David J. Stewart, George A. Wells

Background

We sought to assess the relative effects of individual anaplastic lymphoma kinase (ALK) inhibitors for the treatment of non-small cell lung cancer (NSCLC).

Methods

We searched MEDLINE, Embase, Cochrane CENTRAL, and grey literature (July 23, 2019) for randomized controlled trials (RCTs) that included participants with ALK- or ROS1-positive NSCLC who received any ALK inhibitor compared with placebo, another ALK inhibitor, or the same ALK inhibitor at a different dose. The primary outcome was treatment-related death. Secondary outcomes were overall survival (OS), progression-free survival (PFS), and serious adverse events. Data were pooled via meta-analysis and network meta-analysis, and risk of bias was assessed. PROSPERO: CRD42017077046.

Results

Thirteen RCTs reporting outcomes of interest among participants with ALK-positive NSCLC were identified. Treatment-related deaths were rare, with 10 deaths attributed to crizotinib (risk difference v. chemotherapy: 0.49, 95% credible interval [CrI] –0.16 to 1.46; odds ratio 2.58 (0.76–11.37). All ALK inhibitors improved PSF relative to chemotherapy (hazard ratio [95% CrI]: crizotinib 0.46 [0.39–0.54]; ceritinib 0.52 [0.42–0.64]; alectinib 300 BID 0.16 [0.08–0.33]; alectinib 600 BID 0.23 [0.17–0.30]; brigatinib 0.23 [0.15–0.35]), while alectinib and brigatinib improved PFS over crizotinib and ceritinib (alectinib v. crizotinib 0.34 [0.17–0.70]; alectinib v. ceritinib 0.30 [0.14–0.64]; brigatinib v. crizotinib 0.49 [0.33–0.73]; brigatinib v. ceritinib 0.43 [0.27–0.70]). OS was improved with alectinib compared with chemotherapy (HR 0.57 [95% CrI 0.39–0.83]) and crizotinib (0.68 [0.48–0.96]). Use of crizotinib (odds ratio 2.08 [95% CrI 1.56–2.79]) and alectinib (1.60 [1.00–2.58]) but not ceritinib (1.25 [0.90–1.74), increased the risk of serious adverse events compared with chemotherapy. Results were generally consistent among treatment-experienced or naïve participants.

Conclusion(s)

Treatment-related deaths were infrequent among ALK-positive NSCLC. PFS may be improved by alectinib and brigatinib relative to other ALK inhibitors; however, the assessment of OS is likely confounded by treatment crossover and should be interpreted with caution.

Development and psychometric properties of the maternal health needs scale in Chinese maternal women

There is very limited research on maternal health needs and no reliable validated research tools have been developed. The purpose of this study was to develop and test a Maternal Health Needs Scale (MHNS) in Chinese maternal women.

A meta‐analysis of randomized controlled trials of laughter and humour interventions on depression, anxiety and sleep quality in adults 对成年人抑郁、焦虑和睡眠质量进行笑声和幽默干预措施随机对照试验的荟萃分析

Abstract

Aim

To quantify the effect of laughter and humour interventions on depression, anxiety, and sleep quality in adults.

Design

A meta‐analysis of randomized controlled trials.

Data Sources

PubMed, Embase, PsycINFO, Web of Science, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, Weipu, and Wanfang Data were searched from their inception up to December 2018.

Review methods

The reporting of this meta‐analytical review was conducted according to the guidelines of the Cochrane Collaboration. Two reviewers selected the studies, extracted the data, and evaluated the risk of bias (Cochrane Collaboration bias assessment tool) of the included papers independently.

Results

Ten studies comprising 814 participants were included. Meta‐analysis showed that these interventions significantly decreased adults' depression, anxiety, and improved their sleep quality. The results of subgroup analysis showed that depression benefits more from long‐term laughter intervention.

Conclusions

This meta‐analysis revealed that laughter and humour interventions are effective in relieving depression, anxiety, and improve sleep quality in adults. More studies with high quality and follow‐up assessment should be conducted for future research.

Impact

This review synthesized current evidence using laughter and humour interventions to reduce negative emotion and promote better results in adults, especially with respect to target the applicability between different populations or intervention methods. In addition, humour and laughter interventions are safe, convenient, interesting and can promote interpersonal relationship in both patients and medical workers, which have great feasibility and potential to be used as an aspect of psychotherapy for clinical and nursing to improve well‐beings in adults.

目的

在于量化笑声和幽默干预措施对成年人抑郁、焦虑和睡眠质量的影响。

设计

随机对照试验的荟萃分析。

资料来源

从收录到2018年12月,搜索了PubMed、Embase、PsycINFO、Web of Science、Cochrane对照试验中心注册库、中国期刊全文数据库、维普资讯网和万方数据知识服务平台。

综述方法

本次荟萃分析综述的汇报是根据Cochrane 协作组织的指导方针进行的。两名审查者选择了研究,提取了数据,并分别评价了纳入论文的偏倚风险(Cochrane 协作组织的偏倚评估工具)。

结果

纳入了10项由814名参与者组成的研究。荟萃分析表明,这些干预措施显著降低了成年人的抑郁、焦虑,并改善了他们的睡眠质量。亚组分析的结果表明,长期的笑声干预措施对抑郁症更为大有裨益。

结论

这项荟萃分析显示,笑声和幽默干预措施在缓解成年人的抑郁、焦虑和改善睡眠质量方面卓有成效。应为未来的研究开展更多高质量研究和随访评估。

影响

这篇综述综合了当前的证据,即,使用笑声和幽默干预措施来减少负面情绪,促进更好地成人结果,特别是针对不同人群或干预方法之间的适用性。此外,幽默和笑声干预措施安全、方便、有趣,可以改善患者和医务工作者之间的人际关系,这具有很大的可行性和潜力,可以作为临床和护理心理治疗的一个方面来促进成年人的健康。

Interventions to promote mental health in nursing students: A systematic review and meta‐analysis of randomized controlled trials 促进护生心理健康的干预措施:对随机对照试验的系统评价和荟萃分析

Abstract

Aims

The aim of this study was to systematically examine the efficacy of interventions aimed at improving nursing students’ mental health and to identify which form of interventions was effective.

Background

Recent research has demonstrated mental disorders in common among nursing students and may lead to adverse consequences like low self‐efficacy and poor academic performance.

Design

According to the recommendations of the Cochrane Collaboration, a systematic review and meta‐analysis was conducted.

Data sources

PubMed, EMBase, the Cochrane central register of randomized controlled trials, PsycINFO and Web of Science were used to identify potential studies (January 1990–April 2017).

Review methods

A systematic review of the literature and meta‐analysis of randomized controlled trials on the efficacy of interventions on reducing mental disorders in nursing students. Review Manager version 5.3 was used to obtain pooled results.

Results

Twelve studies with a total sample size of 651 participants met the inclusion criteria. Interventions included psychotherapy, exercise, training programme and other forms of intervention. The results of subgroup analysis showed that depression benefit more from psychotherapy, anxiety benefit from psychotherapy and non‐psychotherapy. Interventions were effective in managing stress and systolic blood pressure. Improvements on self‐efficacy and diastolic blood pressure was not observed.

Conclusion

Psychotherapy should be chosen to reduce depression and anxiety of nursing students. There is a need for further studies should explore more potential value of psychotherapy on stress and biological change.

目的

本研究旨在系统地检测旨在改善护生心理健康的干预措施的有效性,并确定哪种形式的干预措施是有效的。

背景

最近的研究表明,护生普遍存在心理障碍,可能会导致不良后果,如自我效能低下和学习成绩差。

设计

根据科克伦协作网的建议,进行了系统评价和荟萃分析。

数据来源

利用PubMed、EMBase、Cochrane临床对照试验中心注册库、PsycINFO和科学网来确定潜在的研究(1990年1月至2017年4月)。

评价方法

对文献进行系统评价,并对减少护生心理障碍的干预措施的有效性进行荟萃分析。使用Review Manager 5.3软件获得汇总结果。

结果

12项研究的样本总数为651人,符合纳入标准。干预措施包括心理治疗、锻炼、培训课程和其他形式的干预。亚组分析的结果表明,抑郁更多地可以通过心理疗法得到缓解,焦虑可以通过心理疗法和非心理疗法得到缓解。干预措施在控制压力和收缩压方面是有效的。未观察到自我效能和舒张压的改善。

结论

应选择心理疗法来减轻护生的抑郁和焦虑。需要进一步的研究来探索心理疗法对压力和生物学变化的潜在价值。

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