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Vigorous exercise in pragmatic settings leads to antidepressive, metabolic and cardiovascular health benefits in adult outpatients with major depression or anxiety disorders

Por: Morres · I. D. · Metsios · G. S.

Commentary on: Verhoeven JE, Han LKM, Lever-van Milligen BA, et al. Antidepressants or running therapy: comparing effects on mental and physical health in patients with depression and anxiety disorders. J Affect Disord 2023;329:19–29. doi: 10.1016/j.jad.2023.02.064.

Implications for practice and research

  • Supervised outdoor running at vigorous intensity leads to antidepressant and physical health benefits in outpatients with major depression or anxiety disorders.

  • More pragmatic exercise trials for mental health outpatients with heterogeneous symptomatology are needed.

    •  Context

    Exercise is associated with antidepressant effects in clinical settings but relevant research in pragmatic (real-life) settings is scarce.1–3 Hence, Verhoeven et al4 in their pragmatic trial compared the mental and physical health benefits of running therapy versus antidepressant medication.

     Methods

    Participants were physically inactive adult outpatients with a current major depression or an anxiety disorder and were treated with...
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