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Vitamin D supplementation to reduce maternal adverse events: the jury is still out

Por: Martineau · A. R. · Iliodromiti · S.

Commentary on: Borumandnia et al. The impact of vitamin D changes during pregnancy on the development of maternal adverse events: a random forest analysis. BMC Pregnancy and Childbirth 2024;24:125.

Implications for practice and research

  • Data presented in this paper do not demonstrate a cause-effect relationship between maternal vitamin D deficiency during pregnancy and increased risk of maternal adverse events.

  • Randomised controlled trials are needed to resolve uncertainty regarding the effects of vitamin D supplementation in pregnancy on maternal and fetal outcomes.

    • Context

    Sustainable Development Goal Target 3.1 is to reduce maternal mortality to less than 70 maternal deaths per 100 000 live births by 2030. This remains elusive, with 223 maternal deaths per 100 000 live births reported worldwide in 2020.1 Vitamin D plays pleiotropic physiological roles in maintaining calcium homeostasis, modulating the renin-angiotensin axis and regulating insulin secretion.2 Deficiency in...
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