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From sea to cure: Discovery of marine-derived therapeutics against <i>Fusarium solani</i> in shrimps for enhancing aquaculture sustainability

by Abdullah Al Siam, Avijit Kumer Paul, Shanjida Akter Joyoti, Md. Ifteker Hossain, Noimul Hasan Siddiquee, Bushra Binte Zaker, Al- Farabi, Shyamal Kumar Paul

Fusarium solani, an Ascomycota filamentous fungus species, causes shell disease or mycotic infections in wild and farmed shrimps. It causes black gill disease in shrimps, which has no specific treatments, so cutting-edge pharmaceutical research to prevent glutamine synthetase is needed to stop it and reduce its negative effects on aquaculture productivity and health. In silico drug design has been evaluated as an innovative treatment for black gill disease in shrimps caused by F. solani. Initially, molecular docking targeted the Glutamine synthetase (AF-Q9UUN6-F1-v4), utilising a set of 1,191 seaweed metabolites found in the Seaweed metabolite database (SWMD). The three lead compounds, CID: 359 (Phloroglucinol), 11640528 ((6E,10E,14E)-16-(2,5-dihydroxy-3-methylphenyl)-2-hydroxy-2,6,10,14-tetramethyl hexadeca-6,10,14-trien-3-one), and 8768 (Protocatechualdehyde), have binding affinities of −5.752, −5.374, and −5.102 kcal/mol, with negative binding free energies of −16.27, −48.99, and −27.48 kcal/mol, respectively. Additionally, they have excellent ADMET properties, making them safe and effective, whereas HOMO-LUMO and QSAR studies suggest thermodynamic stability and biological activity, notably antifungal efficacy. The compounds were subsequently assessed to verify their durability and binding affinity to the target protein by conducting an MD simulation analysis. In the MD simulation, the ligands evaluated in this study exhibited notable robustness of the proteins’ binding site when complexed with CID: 8768, which suggests a strong interaction between the target and lead compound. Consequently, the compound obtained from the seaweed Polysiphonia lanosa may inhibit the fungal activity of F. solani glutamine synthetase protein, revealing that the compound might be an effective novel therapeutic candidate.

Factors associated with generalised anxiety disorder and depression among adults living with diabetes and hypertension comorbidity in rural Bangladesh: findings from a cross-sectional study

Por: Chakravartty · M. · Shuvo · M. M. S. · Kumari · S. · Jhilik · T. C. · Sarker · T. · Akter · F. · Hossain · M. M. · Ahsan · A. · Latif · M. · Mridha · M. K.
Objective

The rising burden of non-communicable diseases (NCDs), including mental health disorders (MHDs) such as anxiety and depression, poses a significant public health challenge globally. Evidence suggests that both diabetes and hypertension, the two most prevalent NCDs, are linked to a higher prevalence of MHDs. However, there is a lack of evidence on prevalence of generalised anxiety disorder (GAD) and depression among adults living with both diabetes and hypertension in Bangladesh. We aimed to assess the prevalence of GAD and depression and explore the associated factors among adults living with diabetes and hypertension comorbidity in rural Bangladesh.

Design

We implemented a cross-sectional study.

Setting

The study was conducted in Chirirbandar, a sub-district of Dinajpur, Bangladesh.

Participants

We interviewed a total of 387 adults living with diabetes and hypertension comorbidity.

Primary outcome measures

We had two primary outcome measures: GAD and depression. Individuals scoring ≥10 on the General Anxiety Disorder-7 scale were considered as having GAD and individuals scoring ≥10 on the Patient Health Questionnaire-9 scale were considered as having depression. The outcome variables were dichotomised based on these scores.

Results

The prevalence of GAD was 7.24% (95% CI 5.04 to 10.29). Education level (grades 5–9) (adjusted OR (AOR): 3.40, 95% CI 1.26 to 9.19) and household wealth status (highest wealth tertile) (AOR: 0.12, 95% CI 0.02 to 0.62) were associated with GAD. The prevalence of depression was 17.83% (95% CI 14.32 to 21.98). Socioeconomic factors associated with depression included unemployment (AOR: 3.26, 95% CI 1.05 to 10.10) and household wealth status (highest wealth tertile) (AOR: 0.45, 95% CI 0.21 to 0.98). Higher odds of depression were also observed among participants with controlled hypertension (AOR: 3.88, 95% CI 1.81 to 8.35). Other factors, such as tobacco use, dietary diversity and physical activity, were not associated with GAD or depression.

Conclusion

A high prevalence of GAD and depression was observed among adults living with diabetes and hypertension comorbidity. The findings from the study emphasise the need for integration of mental health services into the existing non-communicable disease care. The identified factors associated with GAD or depression should be considered to develop targeted interventions for people with hypertension and diabetes comorbidity in Bangladesh.

Exploring computer vision syndrome among primary school students in Dhaka, Bangladesh: a cross-sectional study

Por: Emon · H. H. · Pingky · J. S. · Halder · H. · Karmaker · S. · Rahman · M. · Shishir · F. M. · Tithi · T. R. · Akter · S. · Rahman · M. · Hossain · M. M.
Background

The use of different electronic devices is increasing among students due to rapid advancements in digital technology. The prevalence of computer vision syndrome (CVS) has increased among school children after the COVID-19 pandemic. Different symptoms of CVS, such as eye strain, headache, blurred vision and visual discomfort, have become major public health problems. This study aimed to assess the prevalence of CVS, identify its risk factors, evaluate parental awareness and examine the impact of COVID-19 on screen time among primary school children in Dhaka, Bangladesh.

Methods

Primary data were collected from the parents of 500 primary school students aged 5–14 years using a convenience sampling method through face-to-face interviews. A structured questionnaire was administered to collect demographic information, screen usage patterns, ambient conditions and details regarding the children’s academic performance. The Computer Vision Syndrome Questionnaire scale was used to assess the prevalence and severity of CVS. Various statistical analyses were performed, including 2 tests, Fisher’s exact tests and logistic regression, to identify significant predictors of CVS (p

Results

Findings revealed that 16.4% of children were affected by CVS, with key risk factors including age, school year, maternal education and daily screen time. Children with CVS commonly reported headaches and itchy eyes, which negatively impacted their academic performance. Surprisingly, 67.4% of parents were unaware of CVS, and the odds of developing CVS were 3.74 times higher among children using electronic devices for more than 4 hours daily.

Conclusions

The study explored the low prevalence of CVS among primary school students in Dhaka, Bangladesh. Several symptoms, like headaches and eye discomfort, were identified that impaired their academic performance. Additionally, many parents were largely unaware of CVS. Therefore, it is necessary to take proper strategies to be aware of the consequences and lessen the prevalence of CVS to save our future generation.

Joint modelling of anthropometric child undernutrition indicators to identify their risk factors in Bangladesh: evidence from the Multiple Indicator Cluster Survey (MICS) 2019

Por: Amin · R. · Akter · T. · Ferdous · R. · Akter · R. · Shahriar · M. M. · Islam · M. A.
Objective

Stunting, wasting and underweight are the three widely recognised indicators of child undernutrition. This study aimed to simultaneously model all indicators while accounting for their association using a joint modelling technique to identify their risk factors.

Design

This was a cross-sectional study design.

Setting

The anthropometric data of children were elicited from the Bangladesh Multiple Indicator Cluster Survey (MICS) 2019.

Main outcome measures

Stunting, wasting and underweight were the main outcome measures of child undernutrition. Initially, a generalised linear mixed model (GLMM) was developed for each indicator separately to identify the underlying risk factors by considering children within the cluster (district level) as hierarchically nested. Finally, a joint model was developed by combining the separate GLMMs with the condition of correlated cluster-specific (district-specific) random effects.

Results

The developed joint model provided precise effects of the risk factors and quantified the association among stunting, wasting and underweight. The joint correlations of underweight with stunting and underweight with wasting were significantly positive based on the predictors in the joint model. The age of children, household wealth status, and maternal education were risk factors for both stunting and underweight. The mother’s age at first birth and the episode of fever were significantly correlated with both underweight and wasting, while the episode of fever was significantly associated with underweight. The region, residence and sex of children were significantly associated with all undernutrition indicators.

Conclusions

This study demonstrates the application of a joint model to simultaneously identify the risk factors associated with indicators of child undernutrition. The study findings reveal a substantial positive association between stunting and underweight, as well as between underweight and wasting, with shared risk factors contributing to the disparity in the prevalence of all forms of child undernutrition in Bangladesh.

Unravelling the impact of social isolation and nursing home placement in older adults: where do we go from here?

Por: Akter · N. · Fick · D. M.

Commentary on: Pomeroy ML, Cudjoe TKM, Cuellar AE, et al. Association of social isolation with hospitalization and nursing home entry among community-dwelling older adults. JAMA Int Med. 2023; 183(9): 955–62. https://doi.org/10.1001/jamainternmed.2023.3064

Implications for practice and research

  • Social isolation is a significant risk factor for nursing home placement for older adults, and public health interventions to improve social connections are urgently needed.

  • Future research should address interventions across the lifespan and for those more vulnerable to isolation and loneliness, testing practical ways to improve social connectiveness.

  • Context

    The quality of our lives is the quality of our relationships. As we approach a challenging time of the year for loneliness and isolation, what do we know about social isolation and healthcare utilisation in older adults? Almost a quarter of community-dwelling older adults experience social isolation.1 There is increasing concern about the effects...

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