Conectar
by Weiyong Chen, Zhongrong Yang, Xing Wang, Weiwei Wang
ObjectiveThis study aimed to investigate the demographic characteristics of Men who have Sex with Men (MSM) recruited online and identify the factorsassociated with meeting homosexual partners at fixed offline locations.
MethodsUnivariate and multivariate logistic regression analyses were used to examine the factors that influenced their meeting up with homosexual partners at fixed offline locations.
ResultsA total of 604 MSM were included, with 133 participants (22.02%) meeting homosexual partners at fixed offline locations. Multivariate logistic regression analysis showed that participantswho were willing to engage in commercial sex, engage in behaviors such as alcohol consumption, drug use, or aphrodisiac use during homosexual activities, and hadused HIVPre-Exposure Prophylaxis (PrEP) in the last six months were more likely to meet homosexual partners at fixed offline locations.
ConclusionsThe proportion of participants meeting homosexual partners at fixed offline locations was relatively high, emphasizing the need to increase education and awareness among MSM to reduce relatedbehaviors during homosexual activities. Further promotion of the proper use of PrEP and avoidance of commercial sex are essential for lowering the risk of HIV infection among this population.
by Yating Li, Xing Wang, Xiaolong Liu, Xiangjie Li, Jianling Zhang, Yulan Li
BackgroundGastric cancer (GC) is a highly malignant gastrointestinal tumor characterized by difficult early diagnosis and poor prognosis. Therefore, it is imperative to explore potential therapeutic targets for gastric cancer. PARP9 is abnormally expressed in a variety of tumors and is associated with tumor cell apoptosis and DNA damage. However, its relationship with GC has not been fully studied.
MethodsThe expression and prognostic significance of PARP9 in gastric cancer (GC) were examined using bioinformatics approaches. Cell lines with either knockdown or overexpression of PARP9 were established through lentiviral transduction, and the role of PARP9 in the malignant phenotypes of GC cells was validated via CCK8 assays, wound healing assays, clonogenic assays, and Transwell migration experiments. Finally, alterations in downstream targets and signaling pathways following changes in PARP9 expression were analyzed through RNA sequencing.
ResultsPARP9 is highly expressed in GC tissues and is associated with poor prognosis. PARP9 knockdown can significantly inhibit the proliferation, invasion and migration of GC cells, and increase the apoptosis and DNA damage of GC cells. The therapeutic process of PARP9 in GC may be realized by synergistic interaction with SOX6 through MAPK signaling pathway.
ConclusionsOur study reveals a potential link between PARP9 and GC, providing a new target for the treatment of GC.
In the meta-analysis, we evaluated the efficacy of placing drainage channels following single- or double-level spine surgery in order to decrease the incidence of postoperative injury. We conducted the analysis with the help of four databases: PubMed, Embase, Cochrane Library and Web of Science. A review of related studies was carried out after evaluating the quality of the literature against the classification and exclusion criteria set for the trial. Calculation of 95% CI, OR and MD was performed with fixed-effect models. A meta-analysis of the data was carried out with RevMan 5.3. Meta-analyses of randomized controlled trial (RCT) did not indicate that there were a statistically significantly different incidence of postoperative wound infections among those who received drainage compared to those who did not receive drainage (OR, 2.29; 95% CI, 0.50, 10.41 p = 0.28). Moreover, there were no statistically significant differences in post-operation hematoma (OR, 1.20; 95% CI, 0.27, 5.28 p = 0.81) and visual analogue scale score (MD, −0.01; 95% CI, −1.34, 1.33 p = 0.99). Thus, placing drainage in short-levels of spine operation did not significantly influence the outcome of postoperative wound complications. Nevertheless, because of the limited sample size chosen for this meta-analysis, caution should be exercised when treating these data. More high-quality RCT trials with a large number of samples are required to confirm the findings.
FreshRSS 