Certain leading medical organisations are considering alternatives to the Body Mass Index (BMI) as a predictor of the risk for non-communicable chronic disease (NCD) or death. Our objective was to evaluate the associations between various measures of body fat and the risk of incident NCDs or mortality, independent of inflammation.

Population-based prospective cohort study (the UK Biobank cohort).

The UK.

Adults (aged between 40 and 69 years) were accrued between March 2006 and October 2010 and followed until December 2022. There were 500 107 participants: the median age was 58 years (IQR 50–63) at baseline, 45.6% were male and 94.7% were white.

BMI, waist-to-hip ratio (WHR), body fat percentage measured by bioimpedance analysis (BIA; fat_BIA), C-reactive protein (CRP) and various other measures of body fat obtained by dual-energy X-ray absorptiometry (DXA; including visceral adipose tissue (VAT)) and magnetic resonance imaging (MRI).

All-cause death, cardiovascular disease (heart failure, hypertension, myocardial infarction, pulmonary embolism and stroke), cancers (breast, colorectal, endometrial, oesophageal, kidney, ovarian, pancreatic and prostate), diabetes, asthma, gallbladder disease, chronic back pain and osteoarthritis.

The 5th and 95th percentiles for measures of body fat were BMI 20.5 (considered ‘healthy’) and 37.0 kg/m² (considered ‘unhealthy’), WHR 0.71 and 0.94 and BIA 24.8% and 47.6% in females, and BMI 22.0 (considered ‘healthy’) and 35.4 kg/m² (considered ‘unhealthy’), WHR 0.83 and 1.05 and BIA 15.5% and 34.7% in males. BMI was strongly correlated to fat_BIA (0.85 in females and 0.80 in males) but less so with WHR (0.46 in females and 0.59 in males). All measures of body fat were positively associated with the incidence of NCDs, but only WHR remained positively associated with death after full adjustment (HR 95th percentile vs 5th percentile (95% CI): BMI 0.80 (0.76 to 0.84), WHR 1.21 (1.16 to 1.28) and BIA 0.80 (0.76 to 0.84) in females; BMI 0.89 (0.85 to 0.93), WHR 1.19 (1.14 to 1.24) and BIA 0.89 (0.85 to 0.92) in males). Simpler models that adjusted for age, sex, CRP, WHR and either BMI or fat_BIA gave similar results. Associations between body fat and the incidence of NCDs after accounting for the competing risk of death were also similar.

BMI was strongly correlated with fat_BIA, but WHR and visceral adipose tissue percentage were less so. All measures of body fat were associated with the incidence of NCDs, but only WHR was independently associated with mortality. These findings support the hypothesis that body fat may be protective against death and that the excess risk associated with higher WHR may be mediated by something other than body fat.

Point-of-care lung ultrasound (LUS) can assist in diagnosing acute respiratory diseases for its high accuracy and immediate availability at the bedside, including older patients with frailty. Delirium represents a frequent complication of hospitalisation in this setting, frequently triggered by acute respiratory diseases. LUS may therefore help identify individuals at risk of delirium, but the association between LUS abnormalities and delirium remains unexplored.

This study is a prospective, observational, multicentre study, with the main objective of assessing the correlation between LUS abnormalities and incident delirium during hospitalisation (primary outcome). The secondary objectives are to assess correlations between lung and diaphragm ultrasound parameters and clinical outcomes including duration of delirium, severity of respiratory failure and mortality. 480 patients aged ≥65 years old, urgently hospitalised after an emergency department visit for acute respiratory complaints, will be recruited in eleven acute geriatric wards located in eight teaching hospitals across Italy. LUS examinations will be performed by skilled clinicians prior to treatment whenever feasible, and in any case within 48 hours from admission. They will also undergo comprehensive geriatric assessment, and daily delirium assessment through the 4-AT tool. The association between LUS abnormalities, related parameters (LUS score, Pleural Effusion Score) and outcomes will be assessed by linear and logistic regression models.

Ethics Committee approval of the coordinating centre (Comitato Etico Territoriale Lombardia 3, reference ID 4369_20.03.2024_M) and collaborative centres has been obtained. All participants will provide written informed consent. Study results will be publicly available following peer-reviewed publication in international scientific journals.

NCT06670118.