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The development of effective vaccines targeting human papillomavirus (HPV) has significantly contributed to disease prevention, highly relevant in immunosuppressed patients who have higher incidence of HPV-related cancers than their non-immunosuppressed counterparts. However, the acceptance and uptake of the HPV vaccine among immunosuppressed individuals pose unique challenges. Immunocompromised patients’ acceptance of the HPV vaccine is influenced by multifaceted factors, including concerns about safety and effectiveness, interactions with immunosuppressive medications and uncertainties due to their compromised immunity. This systematic review aims to identify the main factors influencing HPV vaccine acceptance among immunosuppressed patients.
A comprehensive search strategy will be executed across databases such as MEDLINE/PubMed, Embase, Scopus, Web of Science, ScienceDirect, Latin American and Caribbean Literature in Health Sciences, Cumulative Index to Nursing and Allied Health Literature and Cochrane Database. The review will encompass the three WHO-endorsed HPV vaccines (quadrivalent, bivalent and nonavalent) and will consider studies related to HPV vaccines and their administration. The scope includes study focusing on immunosuppressed patients who received organ transplants, cancer treatments or are HIV-positive. No temporal restrictions will be applied, and searches will be conducted until December 2025. Observational studies, including retrospective/prospective cohorts, case–control and cross-sectional studies, reporting factors influencing HPV vaccination in immunosuppressed populations will be included. Studies with overlapping patient populations will be excluded. Data extraction will include study details, demographics, vaccine type, risk/protective factors, outcomes and medical history. Validation and cross-verification will ensure data accuracy. Risk of bias will be assessed using ROBINS-I (Risk Of Bias In Non-randomised Studies of Interventions), and GRADE (Grading of Recommendations Assessment, Development and Evaluation) will rate evidence certainty. Meta-analysis, guided by Cochrane and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, will employ fixed/random-effects models, assessing heterogeneity using I² statistics.
This research will analyse previously published data, so ethical approval is not required. The results of the systematic review will be submitted for publication in a peer-reviewed journal.
CRD42023452537.
Juan Daniel Suárez-Máximo escribe una reseña sobre el capitulo 2 del libro de Marilyn R. McFarland, Hiba B. Wehbe-Alamah “Leininger's Culture Care Diversity and Universality A Worldwide Nursing Theory”, de la editorial Jones & Bartlett Learning, con la fecha de publicación del 2014.
Introducción: La práctica desde enfermería determina un conocimiento amplio del cuidado cultural y como lograr esa vinculación significativa para la mujer que es atendida al momento del parto, con base a ello la teoría propuesta por la Dra. Leininger, permite el comprender la importación de conocer las tradiciones y creencias determinando como favorecerá la salud en esta etapa promoviendo un bienestar materno. Objetivo: Generar una derivación teórica, a partir de la Teoría de la diversidad y de la universalidad de los cuidados culturales, en la cual se abordará el fenómeno de la atención y el cuidado cultural de la mujer al momento del parto. Metodología: Se determina el desarrollo a partir de lo propuesto por Fawcett, quien determina la aplicación 5 pasos para descripción de conceptos, proposiciones y relaciones sobre su derivación teórica, en la que posterior se determina su aplicación en próximas investigaciones para determinar su efectividad desde la práctica de enfermería. Conclusiones: La teoría contribuye a la determinación de integrarse en la práctica e intervenciones de cuidado de enfermería para determinar un cambio con base a lo propuesto en la atención del parto, desde diversas estrategias determinadas por la teoría.
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