To assess the global burden of pressure injuries from 1990 to 2021 and project trends to 2050.
A cross-sectional survey.
Using the Global Burden of Disease 2021 data from 204 countries (1990–2021), we performed a multilevel analysis incorporating age-period-cohort modelling, stochastic frontier analysis and Bayesian projections to 2050. Key metrics included age-standardised incidence rates, disability-adjusted life years and socio-demographic index stratification.
Global incident cases increased by 160.3%, from 1.22 million to 3.18 million. By 2050, cases are expected to reach 8.4 million, with 72.4% in low-middle socio-demographic index areas. Mortality among those aged 95 and older may triple.
The study emphasises the need for global collaboration to address the burden of pressure injuries through equitable prevention and improved healthcare infrastructure, especially in ageing and resource-limited regions.
The escalating global burden of pressure injuries in geriatric populations necessitates evidence-based approaches to optimise healthcare resource allocation and advance nursing-led prevention frameworks.
The STROBE checklist guided reporting.
Global Burden of Disease collaborators extracted the data and analysed it.