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Children with sickle cell disease show a significant decrease in bone mineral density, an increase in resting energy expenditure of more than 15%, a decrease in fat and lean mass as well as a significant increase in protein turnover, particularly in bone tissue. This study aims to evaluate the effectiveness of an increase in food intake on bone mineral density and the clinical and biological complications of paediatric sickle cell disease.
The study is designed as an open-label randomised controlled clinical trial conducted in the Paediatrics Unit of the Orléans University Hospital Centre. Participants aged 3–16 years will be randomly divided into two groups: the intervention group will receive oral nutritional supplements (pharmacological nutritional hypercaloric products) while the control group will receive age-appropriate and gender-appropriate nutritional intake during 12 months. Total body less head bone mineral density will be measured at the beginning and the end of the trial. A rigorous nutritional follow-up by weekly 24 hours recall dietary assessment and planned contacts every 6 weeks will be carried out throughout the study. A school absenteeism questionnaire, intended to reflect the patient’s school productivity, will be completed by participants and parents every 3 months. Blood samples of each patient of both groups will be stocked at the beginning and at the end of the trial, for future biological trial. Clinical and biological complications will be regularly monitored.
The protocol has been approved by the French ethics committee (Comité de Protection des Personnes Sud-Ouest et Outre-Mer 2, Toulouse; approval no: 2-20-092 id9534). Children and their parents will give informed consent to participate in the study before taking part. Results will be disseminated through peer-reviewed journals or international academic conferences.
The qualities of primary healthcare (PHC) make it a very relevant environment for research; however, there is still work to be done to enhance the research capabilities of family physicians in healthcare units. Considering there is no ongoing review that specifically addresses this objective, the proposed goal of this scoping review is to determine the depth of the literature on the current strategies that support research capacity building among family physicians in the context of PHC.
The scoping review will include studies from PubMed, Scopus, Web of Science, Cochrane Library and grey literature, published from 2008 to 2023, that address strategies to promote research capacity building among family physicians in the context of PHC. Only studies published in English, Portuguese or Spanish will be considered. All study designs, including quantitative, qualitative and mixed-methods studies, will be eligible for inclusion. The literature search will be performed from January to March of 2024 and data charting will employ a descriptive-analytical method, systematically summarising study objectives, methodologies, findings and implications. This protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols and the review will employ the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews.
This review does not need ethical approval. Peer-reviewed publications, policy summaries, presentations at conferences and involvement with pertinent stakeholders are all part of our outreach approach.
The Wound-QoL assesses the impact of chronic wounds on patients' health-related quality of life (HRQoL). A 17-item and a shortened 14-item version are available. The Wound-QoL-17 has been validated for multiple languages. For the Wound-QoL-14, psychometric properties beyond internal consistency were lacking. We aimed to validate both Wound-QoL versions for international samples representing a broad range of European countries, including countries for which validation data had yet been pending. Patients with chronic wounds of any aetiology or location were recruited in Austria, Lithuania, the Netherlands, Poland, Slovakia, Spain, Switzerland and Ukraine. Psychometric properties were determined for both Wound-QoL versions for the overall sample and, if feasible, country-wise. We included 305 patients (age 68.5 years; 52.8% males). Internal consistency was high in both Wound-QoL-17 (Cronbach's α: 0.820–0.933) and Wound-QoL-14 (0.779–0.925). Test–retest reliability was moderate to good (intraclass correlation coefficient: 0.618–0.808). For Wound-QoL-17 and Wound-QoL-14, convergent validity analyses showed highest correlations with global HRQoL rating (r = 0.765; r = 0.751) and DLQI total score (r = 0.684; r = 0.681). Regarding clinical data, correlations were largest with odour (r = −0.371; r = −0.388) and wound size (r = 0.381; r = 0.383). Country-wise results were similar. Both Wound-QoL versions are valid to assess HRQoL of patients with chronic wounds. Due to its psychometric properties and brevity, the Wound-QoL-14 might be preferrable in clinical practice where time is rare. The availability of various language versions allows for the use of this questionnaire in international studies and in clinical practice when foreign language patients are being treated.
Chronic wounds can severely limit patient's social life. This cross-sectional study investigated quantitatively social support of patients with chronic wounds, its association with health-related quality of life as well as qualitatively changes in social participation of these patients. Overall, 263 patients from seven countries participated. The most frequent wound class was leg ulcer (49.2%). Results revealed generally high levels of social support (mean global score: 5.5) as measured with the Multidimensional Scale of Perceived Social Support. However, individuals differed considerably (range 1.0–7.0). All dimensions of social support differed by patients' family and living situations (p < 0.001 to p = 0.040) and were positively correlated with generic health-related quality of life (r = 0.136–0.172). Having children, living with others and being in a relationship were significant predictors of having higher global social support. Patients reported great support from family members. Many participants reported no changes in relationships with friends. Wound care managers took an important role and provided additional emotional support. Patients reported a range of discontinued activities. Despite the high overall level of social support, inter-individual differences should be acknowledged. The importance of family carers should be acknowledged to be able to reduce caregiver burden and to ensure high-qualitative wound care.
Health information systems represent an opportunity to improve the care provided to people with multimorbidity. There is a pressing need to assess their impact on clinical outcomes to validate this intervention. Our study will determine whether using a digital platform (Multimorbidity Management Health Information System, METHIS) to manage multimorbidity improves health-related quality of life (HR-QoL).
A superiority, cluster randomised trial will be conducted at primary healthcare practices (1:1 allocation ratio). All public practices in the Lisbon and Tagus Valley (LVT) Region, Portugal, not involved in a previous pilot trial, will be eligible. At the participant level, eligible patients will be people with complex multimorbidity, aged 50 years or older, with access to an internet connection and a communication technology device. Participants who cannot sign/read/write and who do not have access to an email account will not be included in the study. The intervention combines a training programme and a customised information system (METHIS). Both are designed to help clinicians adopt a goal-oriented care model approach and to encourage patients and carers to play a more active role in autonomous healthcare. The primary outcome is HR-QoL, measured at 12 months with the physical component scale of the 12-item Short Form questionnaire (SF-12). Secondary outcomes will also be measured at 12 months and include mental health (mental component Scale SF-12, Hospital Anxiety and Depression Scale). We will also assess serious adverse events during the trial, including hospitalisation and emergency services. Finally, at 18 months, we will ask the general practitioners for any potentially missed diagnoses.
The Research and Ethics Committee (LVT Region) approved the trial protocol. Clinicians and patients will sign an informed consent. A data management officer will handle all data, and the publication of several scientific papers and presentations at relevant conferences/workshops is envisaged.
Paciente de 5 años con diagnóstico de neuroblastoma abdominal metastásico de alto grado desde 2022, acude a la unidad de trasplante infantil para someterse a megaterapia con Busulfan y Melfalan como tratamiento mieloabrasivo, con posterior rescate mediante trasplante autólogo de progenitores hematopoyético (TPH). Tras realizar la valoración enfermera por patrones de M. Gordon en dos momentos, al ingreso y tras el trasplante, se detectó la alteración de 6 patrones y se estableció un plan de cuidados individualizado, que incluye al paciente y a la cuidadora principal, empleándola taxonomía NANDA-NOC-NIC.
Objetivo principal: Valorar si la terapia con sanguijuelas, es beneficiosa en el alivio de la congestión venosa. Metodología: Lectura crítica con CARE. Resultados principales: Nivel de evidencia bajo, según GRADE. Conclusión principal: A pesar de la falta de evidencia, con-cluimos que la terapia con sanguijuelas, mejora la congestión venosa en heridas.
Objetivo principal: Evaluar la efectividad de la miel para la tos aguda en niños. Metodología: Lectura crítica con CASPe y Prisma 2. Pro-cedimientos metodológicos estándar esperados por Cochrane. Resultados principales: Nivel de evidencia baja. Conclusión principal: A pesar de la falta de evidencia plausible,la miel puede reducir la tos aguda en niños, frente a la no utilización de otro producto, tomándo-se como una recomendación favorable pero no concluyente, siendo mayor el beneficio obtenido que el perjuicio.
Objetivo principal: Valorar si masticar chicle, tras una cesárea, mejora la función intestinal. Metodología: Lectura crítica con CASPe y Prisma 2. Resultados principales: Nivel de evidencia baja, según GRADE. Conclusión principal: A pesar de una falta de evidencia plausible, concluimos que masticar chicle, mejora la recuperación temprana de la función intestinal.
Objetivo principal: cuantificar el ruido ambiental en una unidad de cuidados intensivos y detectar las fuentes que generan los picos más altos de ruido. Metodología: se llevó a cabo un estudio observacional descriptivo en una unidad de cuidados intensivos de adultos. Se realizaron veinticinco mediciones del ruido ambiental, no consecutivas, aleatorias, durante las 24 horas del día. El nivel de ruido fue medido en decibelios. Los datos obtenidos fueron analizados descriptivamente. Resultados principales: la media de los picos máximos de ruido registrados fue de 80.8 ± 4.05 decibelios y la media de los picos mínimos fue de 37.8 ± 1.3 decibelios. El nivel de significación considerado para todos los contrastes fue p< 0.05. Los picos máximos de ruido coincidieron con las alarmas de los monitores, las llamadas telefónicas, con algunas conversaciones y con el paso del carro de las comidas. Conclusión principal: los niveles de ruido ambiental registrados fueron elevados y estuvieron muy por encima de las recomendaciones dictadas por la Organización Mundial de la Salud. Existe la necesidad de establecer estrategias educativas y estructurales para la reducción del ruido. Se proponen una serie de medidas para disminuir el ruido en nuestra unidad.
Artículo en alemán de divulgación científica, cuyo objetivo es dar a conocer la técnica de aposición con pelo para laceraciones tipo scalp (Arrancamiento accidental, total o parcial, del cuero cabelludo), que consiste en el acercamiento de los bordes de la herida mediante el enrollado de haces de pelo colindante y su aseguramiento con pegamento tisular; así como reflejar las ventajas de este método frente a las suturas convencionales y a las grapas. Se trata de una reseña en la sección de “foco de formación” o “foco educativo” de una revista médica [fragmento de texto].
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