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Behaviours as biomarkers? Disentangling causality between vitamin D, sedentary behaviours and mortality is necessary for preventing recurrence and cardiovascular disease in cancer survivors

Por: Giorgi Rossi · P. · Bonvicini · L.

Commentary on: Yu Y, Cheng S, Huang H, et al. Joint association of sedentary behaviour and vitamin D status with mortality among cancer survivors. BMC Med 2023;21:411.

Implications for practice and research

  • Results support National Institute for Health and Care Excellence recommendations7 in defining vitamin D levels below 50 nmol/L as insufficient and highlight sitting time over 6 hours/day as a possible determinant of mortality in cancer survivors.

  • Biological mediators linking sedentary behaviours, vitamin D and health outcomes should be investigated to understand the underlying causal link.

    • Context

    Many observational studies showed that sedentary behaviours1 and low serum levels of vitamin D2 are independent risk factors for mortality in cancer survivors. Nevertheless, data from trials on vitamin D supplementation3 and interventions promoting physical activity4 did not obtain the effect on mortality in cancer survivors that...
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