Eosinophilic esophagitis and its association with food allergies: A United States national analysis 2016 to 2022

by Misha Shah, Abhin Sapkota, Ishaan Aravindaksha, Gedion Yilma Amdetsion, Kriti Katwal, Anas Almoghrabi

Background

Eosinophilic esophagitis (EoE) has known associations with allergic conditions. Previous studies have reported an increased frequency of EoE in patients with IgE-mediated food allergies (FA), however, statistical validation in large inpatient cohorts remains limited.

Methods and Findings

A retrospective analysis was performed using the National Inpatient Sample (NIS) database from 2016 to 2022. International Classification of Diseases, 10th Revision (ICD-10) codes were used to identify patients with a primary or secondary diagnosis of EoE and FA. Multivariable logistic regression was performed to assess the relationship between EoE and FA. Multivariable regression analysis showed a strong association between EoE and milk (aOR: 7.52, p  Conclusions

Our study supports a strong association between EoE and milk, egg, peanut, and seafood allergies, and the findings across demographics show notable disparities.