Conectar
by Ziyue Wang, Bowen Lu, Hao Yang, Weijie Zhao, Xinru Kong, Chuanhao Mi, Jianlin Wu
ObjectiveEdaravone is a neuroprotective agent, but the characteristics of its adverse events (AEs) remain insufficiently explored. This study aims to examine AEs associated with edaravone use by analyzing real-world data from the FDA Adverse Event Reporting System (FAERS).
MethodsThis retrospective study extracted adverse event reports related to edaravone from the FAERS database, spanning from the second quarter of 2017 to the second quarter of 2024. Disproportionality analysis methods, including the Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), and Bayesian Confidence Propagation Neural Network (BCPNN), were employed to detect AE signals associated with edaravone use.
ResultsAmong 2,931 adverse event reports (AERs) in which edaravone was identified as the primary suspected drug, 86 preferred terms (PTs) and 20 system organ classes (SOCs) were included. At the PTs level, the significant drug-related adverse events were death (n = 589, ROR = 8.64), disease progression (n = 266, ROR = 28.26) and drug ineffectiveness (n = 252, ROR = 2.16). Additionally, rare but notably strong adverse event signals were observed, including thrombosis at the catheter site thrombosi, gastric fistula, and vein collapse.
ConclusionOur research found that edaravone has some overlooked adverse reactions. Further epidemiological studies are needed to more comprehensively explore and assess the risk-benefit profile of edaravone.
To explore the factors influencing the intention of patients with coronary heart disease to undergo cardiac rehabilitation.
This is a qualitative content analysis study.
Semi structured, face-to-face interviews were conducted in the Department of Cardiology at a tertiary Grade-A hospital in Baoding, China, from January to March 2025. To ensure sample diversity, purposeful sampling was employed. The interview guide was based on the Reasoned Action Approach theory, literature review, and team deliberations. Data were analysed using deductive content analysis.
Twenty patients with coronary heart disease participated in the interviews (average age 57.9 years; 10 males, 10 females; 0–360 months disease course). Nine themes were identified from the three dimensions of RAA attitudes, perceived norms, and perceived behavioural control, reflecting patients' attitudes regarding cardiac rehabilitation (rehabilitation is beneficial, safety concerns, and non-essential treatment strategy); the impact of external factors on cardiac rehabilitation in patients (lack of professional recommendations, lack of awareness among friends and family); and barriers and facilitators in the implementation of cardiac rehabilitation (limited resources, insufficient self-efficacy, responsibility-driven, and individualised needs are challenging to fulfil).
To enhance the cardiac rehabilitation intentions of patients with coronary heart disease, healthcare providers should comprehensively assess influencing factors from the patient's perspective. Tailored interventions should focus on cognitive restructuring, support system enhancement, and patient empowerment.
This study highlights factors influencing patients' cardiac rehabilitation intentions. Nurses, equipped with relevant knowledge and skills, can provide systematic cardiac rehabilitation education during hospitalisation, thereby enhancing intentions and improving participation in cardiac rehabilitation.
This study adheres to the Consolidated Criteria for Reporting Qualitative Research (COREQ) checklist guidelines.
Patients with coronary heart disease participated in the interviews and provided essential insights for this study.
FreshRSS 