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Deep brain stimulation (DBS) is a proven effective treatment for Parkinson’s disease (PD). However, titrating DBS stimulation parameters is a labourious process and requires frequent hospital visits. Additionally, its current application uses continuous high-frequency stimulation at a constant intensity, which may reduce efficacy and cause side effects. The objective of the AI-DBS study is to identify patient-specific patterns of neuronal activity that are associated with the severity of motor symptoms of PD. This information is essential for the development of advanced responsive stimulation algorithms, which may improve the efficacy of DBS.
This longitudinal prospective observational cohort study will enrol 100 patients with PD who are bilaterally implanted with a sensing-enabled DBS system (Percept PC, Medtronic) in the subthalamic nucleus as part of standard clinical care. Local neuronal activity, specifically local field potential (LFP) signals, will be recorded during the first 6 months after DBS implantation. Correlations will be tested between spectral features of LFP data and symptom severity, which will be assessed using (1) inertial sensor data from a wearable smartwatch, (2) clinical rating scales and (3) patient diaries and analysed using conventional descriptive statistics and artificial intelligence algorithms. The primary objective is to identify patient-specific profiles of neuronal activity that are associated with the presence and severity of motor symptoms, forming a ‘neuronal fingerprint’.
Ethical approval was granted by the local ethics committee of the Amsterdam UMC (registration number 2022.0368). Study findings will be disseminated through scientific journals and presented at national and international conferences.
by Geertje van Wijk, Lisa van Antwerpen, Femke A. Hoefnagels, Sjef J. J. M. Staps, Marieke C. E. Battjes-Fries
ObjectiveAn increasing number of children in the Netherlands is overweight or obese, which is largely attributable to an unhealthy lifestyle and unhealthy living environment. Nutrition education and greening the schoolyard, for example with a vegetable garden, have independently been studied and are shown to be effective in teaching children a healthy lifestyle and providing a healthy living environment. However, the feasibility of combining nutrition education and greening the schoolyard has not been studied yet. Therefore, this study aimed to provide insight into primary schools’ vision on making this combination, and the feasibility of doing so.
MethodsIn this study a qualitative research design was used. The theoretical frameworks of Proctor et al. and Sekhon et al. were used to develop the interview guide. Twelve semi-structured interviews were conducted with members of school teams and school directors. The interviews were transcribed verbatim and analyzed using the thematical analysis of Braun and Clarke.
ResultsAccording to the interviewees, three facets are essential to make the combination of greening schoolyards and nutrition education feasible and successful. Firstly, the interviewees mentioned that the school team and school directors of schools must be able to see the connection between greening the schoolyard and nutrition education. Additionally, support is needed among the parents, school team, pupils and local community. Finally, the interviewees stated that schools must be able to integrate greening the schoolyard and nutrition education into their existing curriculum.
ConclusionsThe results of this study showed that combining greening schoolyards and nutrition education in primary schools is feasible and successful when vision, support and integration are present. Future research should investigate the vision of the local community and parents on making the combination, and the effects of the combination on pupils and their environment.
FreshRSS 