Commentary on: Verhoeven JE, Han LKM, Lever-van Milligen BA, et al. Antidepressants or running therapy: comparing effects on mental and physical health in patients with depression and anxiety disorders. J Affect Disord 2023;329:19–29. doi: 10.1016/j.jad.2023.02.064.
Supervised outdoor running at vigorous intensity leads to antidepressant and physical health benefits in outpatients with major depression or anxiety disorders. More pragmatic exercise trials for mental health outpatients with heterogeneous symptomatology are needed.
Exercise is associated with antidepressant effects in clinical settings but relevant research in pragmatic (real-life) settings is scarce.
Participants were physically inactive adult outpatients with a current major depression or an anxiety disorder and were treated with...