Siblings of children with disabilities or chronic illnesses often face significant challenges during their upbringing. Despite these difficulties, many develop a positive outlook and adapt successfully. To help individuals navigate developmental challenges in a healthy and manageable way, this study focuses on the concept of resilience. Although previous studies have primarily focused on the challenges and difficulties faced by siblings of children with disabilities and chronic illnesses, the factors influencing resilience in these siblings remain unclear. This review aims to inform the development of effective support systems for siblings of children with disabilities and chronic illnesses.

We will search PubMed (MEDLINE), CINAHL (EBSCOhost), Web of Science and Ichushi-Web (a Japanese Medical Literature Database). Two independent reviewers will apply the inclusion and exclusion criteria to screen the titles and abstracts of the retrieved articles. Full texts of relevant studies will be reviewed. This scoping review focuses on studies addressing resilience in siblings of children with disabilities and chronic illnesses during childhood, with particular focus on the perspectives of siblings. The review will exclude conference proceedings, abstracts, posters, editorials, commentaries, opinion papers and review papers. However, important documents found during the search will be added if relevant. Using a custom data extraction method developed for this review, the researchers will extract relevant data, inductively and comprehensively organise similar codes, and identify key components of resilience.

This study does not involve human subjects and therefore does not require approval from an ethics committee for human subjects research. The results of this exploratory review will be disclosed through conference presentations and publication in peer-reviewed academic journals.

https://osf.io/p34ex/

Zika virus (ZIKV) infection during pregnancy has been associated with adverse birth outcomes, including congenital Zika syndrome, characterised by features such as microcephaly. However, the broader neurodevelopmental influence of prenatal ZIKV exposure, especially among offspring without congenital anomalies at birth, remains poorly understood. While previous studies, including a review, have explored neurodevelopment in ZIKV-exposed children, comparative pooled estimates between exposed and unexposed groups remain scarce. This systematic review and meta-analysis aims to evaluate the association between prenatal ZIKV exposure and neurodevelopmental outcomes in offspring without congenital anomalies at birth, using data from observational studies with defined control groups.

We will systematically search multiple databases, including PubMed, EMBASE, Scopus, CINAHL, PsycINFO, Cochrane Library and Web of Science, alongside grey literature sources such as Google Scholar and conference proceedings. Eligible studies will include observational designs (cohort and case-control) comparing neurodevelopmental outcomes between children with and without prenatal ZIKV exposure. Primary outcomes will include gross motor, fine motor, communication, problem-solving, social-emotional and cognitive development assessed with validated tools. Three reviewers will independently screen studies, extract data and assess methodological quality using the Newcastle-Ottawa Scale and the Grading of Recommendations, Assessment, Development and Evaluation approach. A meta-analysis will be conducted where appropriate, with heterogeneity assessed using the I² statistic and further explored through subgroup and meta-regression analyses.

Ethical approval is not required, as the study involves secondary analysis of publicly available data. Findings will be disseminated through peer-reviewed publications and conference presentations.

CRD420251011184.