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☐ ☆ ✇ BMJ Open

Gender disparities in COVID-19 vaccine hesitancy in high-income countries: an umbrella review protocol

Por: Wiedermann · C. J. · Noviello · C. · Palmieri · C. · Stefanizzi · P. · Piccoliori · G. · Engl · A. · Tafuri · S. — Julio 4th 2025 at 04:45
Introduction

Vaccine hesitancy remains a critical public health challenge, especially in high-income countries. Gender differences in vaccine hesitancy can significantly affect vaccination rates and public health outcomes. The aim of this research is performing an umbrella review and meta-analysis to systematically investigate gender disparities in vaccine hesitancy for COVID-19 in high-income countries, as well as the quality, potential biases and dependability of epidemiological evidence.

Methods and analysis

The study will systematically search, extract and analyse data from reported systematic reviews and meta-analyses that focus specifically on gender differences in vaccine hesitancy. The search will include CINAHL, Cochrane Library, PubMed/MEDLINE, EMBASE and Epistemonikos for studies published from 2019 onward. The inclusion criteria will encompass systematic reviews and meta-analyses of non-interventional studies conducted in high-income countries. The identified factors contributing to vaccine hesitancy will be categorised based on demographic, psychological, social and economic dimensions. The methodological quality of the included meta-analyses will be assessed using the "Joanna Briggs Institute Critical Appraisal Checklist for Systematic Reviews and Research Syntheses" tool.

Ethics and dissemination

Ethical approval is not required for this umbrella review. These results will be published in a peer-reviewed journal.

PROSPERO registration number

CRD42024572978.

☐ ☆ ✇ Worldviews on Evidence-Based Nursing

A Multinational Observational Study of Nurse Work Wellbeing: A Research Protocol for the Caring Science International Collaborative

ABSTRACT

Background

Work wellbeing, also known as workplace wellbeing, is a global concern for nurses, particularly because excessive stress and exhaustion contribute to burnout.

Objective

The Caring Science International Collaborative (CSIC), an international research network, empirically investigates nurse work wellbeing using the Profile of Caring, a psychometrically validated and reliable instrument.

Framework

The CSIC framework defines wellbeing intrinsically—as caring and clarity—and extrinsically—as the social and technical resources needed to work efficiently and effectively. The Profile of Caring explains 80% of work wellbeing in nursing without bias across 10 countries.

Study Design

This research protocol describes an international multicenter observational study that measures nurse work wellbeing using the Profile of Caring and other concepts and outcomes measures.

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