Central venous catheters (CVCs) are commonly used in intensive care but should be removed as soon as they are no longer needed to reduce infection risk. Peripheral venous access then becomes necessary, but can be challenging due to oedema. Near-infrared light devices, simple non-invasive tools, may assist nurses in this procedure. We hypothesise that a near-infrared light device (AccuVein AV500) could improve the first-attempt success rate of peripheral venous catheter (PVC) placement in intensive care patients no longer requiring a central catheter.

This investigator-initiated, prospective, multicentre, randomised controlled superiority trial compares the near-infrared light device to the landmark approach for PVC insertion in critically ill patients with an existing CVC. A total of three hundred and eighty patients are to be randomised in two parallel groups with a stratification on centre and anticipated difficulty of peripheral venous access.

The study objective is to compare the first-attempt success rate of PVC placement in adult critical care patients for whom a central catheter is no longer indicated.

The protocol and amendments have been approved by the French ethics committee (Comité de Protection des Personnes Sud Ouest et Outre Mer II, Toulouse, France, number 2023-A00429-36), and patients are included after informed consent. The results will be submitted for publication in peer-reviewed journals.

Clinicaltrials.gov: NCT06234293.