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☐ ☆ ✇ Journal of Nursing Scholarship

Beyond order‐based nursing workload: A retrospective cohort study in intensive care units

Por: Yi Chen · Carri W. Chan · Jing Dong · Emily M. Jackson · Natalie H. Yip · Sarah C. Rossetti — Mayo 13th 2024 at 06:39

Abstract

Introduction

In order to be positioned to address the increasing strain of burnout and worsening nurse shortage, a better understanding of factors that contribute to nursing workload is required. This study aims to examine the difference between order-based and clinically perceived nursing workloads and to quantify factors that contribute to a higher clinically perceived workload.

Design

A retrospective cohort study was used on an observational dataset.

Methods

We combined patient flow, nurse staffing and assignment, and workload intensity data and used multivariate linear regression to analyze how various shift, patient, and nurse-level factors, beyond order-based workload, affect nurses' clinically perceived workload.

Results

Among 53% of our samples, the clinically perceived workload is higher than the order-based workload. Factors associated with a higher clinically perceived workload include weekend or night shifts, shifts with a higher census, patients within the first 24 h of admission, and male patients.

Conclusions

The order-based workload measures tended to underestimate nurses' clinically perceived workload. We identified and quantified factors that contribute to a higher clinically perceived workload, discussed the potential mechanisms as to how these factors affect the clinically perceived workload, and proposed targeted interventions to better manage nursing workload.

Clinical Relevance

By identifying factors associated with a high clinically perceived workload, the nurse manager can provide appropriate interventions to lighten nursing workload, which may further reduce the risk of nurse burnout and shortage.

☐ ☆ ✇ Nursing Research

Research and Policy

Por: Pickler · Rita H. — Mayo 1st 2024 at 02:00
No abstract available
☐ ☆ ✇ Evidence-Based Nursing

Early career nurse researchers: insights, challenges and strategies for success

Por: Sisson · H. — Marzo 28th 2024 at 14:43

The term early career researcher (ECR) is commonly used, although its meaning is expressed by a wide range of definitions which vary globally, and may be institutionally determined.1 2 Length of time since the start or completion of doctoral training (or equivalent professional training) or a first academic appointment is often used by research councils such as the UK Research and Innovation (UKRI) (see Early career researchers–UKRI). Stage of career is also sometimes referred to with ECRs being a catch-all term for doctoral and immediately postdoctoral researchers as well as those making the transition to an independent research career (see Early career researchers–UKRI).

Increasingly, the challenges associated with such time-bound definitions of ECRs are being acknowledged. Many bodies which offer funding for ECRs (eg, see Early career research fellowships–InterAct Hub (interact-hub.org) and Early career researchers: career and skills development–UKRI)...

☐ ☆ ✇ Evidence-Based Nursing

How healthy dietary patterns have an impact on overall and cause-specific mortality?

Por: Nguyen · N. T. H. · Duong · T. V. — Marzo 28th 2024 at 14:43

Commentary on: Shan Z, Wang F, Li Y, Baden MY, Bhupathiraju SN, Wang DD, Sun Q, Rexrode KM, Rimm EB, Qi L, Tabung FK, Giovannucci EL, Willett WC, Manson JE, Qi Q, Hu FB. Healthy Eating Patterns and Risk of Total and Cause-Specific Mortality. JAMA Intern Med. 2023 Feb 1;183(2):142-153. doi: 10.1001/jamainternmed.2022.6117. Erratum in: JAMA Intern Med. 2023 Jun 1;183(6):627.

Implications for practice and research

  • Wholesome eating diets can be customised to align with person’s culinary traditions and tastes in accordance with the Dietary Guidelines for Americans to decrease the mortality risk.

  • Provide updated scientific evidences on the benefits of maintaining a healthy diet throughout the life course to take appropriate strategies and policies.

  • Context

    Healthy eating patterns play a prominent role in preserving public health. The association between dietary patterns with the mortality risk has been investigated in numerous countries.1 2

    ☐ ☆ ✇ Evidence-Based Nursing

    Digital assets should be included in advance care planning discussions for patients receiving palliative care

    Por: Al Qadire · M. · Abdelrahman · H. — Marzo 28th 2024 at 14:43

    Commentary on: Stanley S, Higginbotham K, Finucane A, Nwosu AC. A grounded theory study exploring palliative care healthcare professionals’ experiences of managing digital legacy as part of advance care planning for people receiving palliative care. Palliat Med. 2023 Oct;37(9):1424–1433. doi: 10.1177/02692163231194198. Epub 2023 Aug 23.

    Implications for practice and research

  • Digital legacy could be incorporated into advance care planning policies in practice, with explicit inclusion in advance care planning documents.

  • Further research is required to explore the diverse facets of digital legacies within various patient populations and cultural backgrounds.

  • Context

    The rapid growth of technology, including increased internet access and smartphone usage, has made digital legacy management an important aspect of end-of-life care. Digital legacy refers to the digital assets and online presence that individuals leave behind after they pass away.1 However, a study on healthcare professionals indicated that a significant majority...

    ☐ ☆ ✇ Evidence-Based Nursing

    Trajectory patterns of self-care behaviour over 1 year provide nurses insights to tailor individualised care for patients with heart failure

    Por: Chang · W.-T. · Chen · H.-M. — Marzo 28th 2024 at 14:43

    Commentary on: Son YJ, Jang I. One-year trajectories of self-care behaviours and unplanned hospital readmissions among patients with heart failure: A prospective longitudinal study. J Clin Nurs. 2023 Sep;32(17-18):6427-6440. doi: 10.1111/jocn.16658. Epub 2023 Feb 23.

    Implications for practice and research

  • Timely identifying self­care behaviour patterns over time may reduce the risk of hospital readmissions in patients with heart failure (HF).

  • Further research studies are required to examine the effects of every 3–6 months self-care intervention on hospital readmissions among patients with HF.

  • Context

    Unplanned readmissions within 30 days and 6 months postdischarge are notably common in patients with HF.1 2 Effective self-care behaviours are essential to lower readmissions. However, the trajectories of self-care behaviours throughout the HF progression can vary among patients.3 Limited research studies have examined the relationships among the influencing variables, self-care behaviours and readmissions over...

    ☐ ☆ ✇ Journal of Advanced Nursing

    Sustainable employability of long‐term care staff in self‐managing teams: A qualitative study

    Abstract

    Aim

    To discover what long-term care (LTC) staff working in self-managing teams consider necessary to remain sustainably employable.

    Design

    Qualitative study with semi-structured interviews.

    Methods

    In 2020, semi-structured interviews were conducted one-on-one with 25 LTC workers from a medium-large Dutch organization providing long-term care. All interviews were audio-recorded, anonymously transcribed verbatim and analysed with thematic content analysis in the software program Atlas.ti.

    Results

    LTC workers indicated a need for autonomy. They wanted their control and involvement in decisions to be strengthened. Furthermore, LTC workers indicated a need for relatedness, by experiencing support, a feeling of togetherness and more time to have attention for the residents. Lastly, LTC workers expressed a need for (assistance in) further developing their competence.

    Conclusion

    In order to remain willing and able to work, LTC workers in self-managing teams want their needs for autonomy, relatedness and competence to be addressed. Working conditions are important to these LTC workers' sustainable employability since they can hinder or promote the satisfaction of their needs.

    Implications

    It is important that management in LTC is aware of the importance of LTC workers' needs for sustainable employability. We recommend that management critically reflect on and invest in addressing these needs by enhancing indicators and limiting inhibitors of the needs.

    Impact

    A robust LTC workforce is necessary to provide care to the aging population. In the context of the increasing implementation of self-managing teams in LTC organizations, understanding what workers in self-managing teams need in order to remain sustainably employable is crucial. For sustainable employability (i.e. to remain willing and able to work), interviewees indicated a need for autonomy, relatedness, and competence. Nearly all participants stressed the importance of belonging and feeling connected. Working conditions seemed to relate not only directly to the sustainable employability of LTC staff but also indirectly through their lack of contribution to the satisfaction of workers' psychological needs. The outcomes of this study primarily impact workers and management within LTC organizations with self-managing teams. They benefit from recognizing the significance of addressing workers' needs to ensure their essential and sustainable employability in the sector.

    Reporting Method

    The Standards for Reporting Qualitative Research and the Consolidated Criteria for Reporting Qualitative (COREQ) research were used.

    Patient or Public Contribution

    Two LTC workers provided advice and feedback regarding the materials and set up of the interviews. These two ambassadors additionally helped in reaching our population, by disseminating information about the study.

    ☐ ☆ ✇ Journal of Clinical Nursing

    Exploring the relationship between AM‐PAC scores and mobility components in falls and pressure injury risk assessment tools: A pathway to improve nursing clinical efficiency

    Por: Jan Stenum · Kevin McLaughlin · Ioannis Collector · Karli Funk · Lydia Vincent · Daniel Young · Ann Hendrich · Erik H. Hoyer — Marzo 21st 2024 at 08:05

    Abstract

    Background

    Nurses routinely perform multiple risk assessments related to patient mobility in the hospital. Use of a single mobility assessment for multiple risk assessment tools could improve clinical documentation efficiency, accuracy and lay the groundwork for automated risk evaluation tools.

    Purpose

    We tested how accurately Activity Measure for Post-Acute Care (AM-PAC) mobility scores predicted the mobility components of various fall and pressure injury risk assessment tools.

    Method

    AM-PAC scores along with mobility and physical activity components on risk assessments (Braden Scale, Get Up and Go used within the Hendrich II Fall Risk Model®, Johns Hopkins Fall Risk Assessment Tool (JHFRAT) and Morse Fall Scale) were collected on a cohort of hospitalised patients. We predicted scores of risk assessments based on AM-PAC scores by fitting of ordinal logistic regressions between AM-PAC scores and risk assessments. STROBE checklist was used to report the present study.

    Findings

    AM-PAC scores predicted the observed mobility components of Braden, Get Up and Go and JHFRAT with high accuracy (≥85%), but with lower accuracy for the Morse Fall Scale (40%).

    Discussion

    These findings suggest that a single mobility assessment has the potential to be a good solution for the mobility components of several fall and pressure injury risk assessments.

    ☐ ☆ ✇ Journal of Advanced Nursing

    Sense of coherence moderates job demand‐resources and impact on burnout among nurses and midwives in the context of the COVID‐19 pandemic: A cross‐sectional survey

    Por: C. Paterson · D. Davis · C. Roberts · K. Bail · E. Wallis · H. L. Northam · J. Frost · N. Jojo · C. McGrory · A. Dombkins · P. S. Kavanagh — Marzo 1st 2024 at 09:00

    Abstract

    Aim

    This study aimed to test the propositions using the job demands-resources (JD-R) model for main/moderation/mediation effects of a sense of coherence and practice environment support on mental well-being (anxiety, depression and burnout) outcomes in nurses and midwives in Australia during the COVID-19 pandemic.

    Design

    Cross-sectional quantitative survey.

    Data Sources

    The study was a cross-sectional design using self-report questionnaires reported as per the Reporting of Observational Studies in Epidemiology Guidelines. Following human research ethics approval (2020.ETH.00121) participants were recruited to take part in an online anonymous survey using self-report instruments to test the JD-R model in Australia.

    Results

    156 participant nurses and midwives experienced anxiety, depression and emotional burnout during COVID-19. While a considerable proportion of participants indicated high levels of emotional exhaustion, their responses showed low levels of depersonalization (detached response to other people) and high levels of personal accomplishment (high levels of work performance and competence). A sense of coherence was a significant protective factor for mental health well-being for the participants, which is to say, high levels of sense of coherence were predictive of lower levels of anxiety, depression and burnout in this study sample.

    Conclusion

    It is evident that both nursing and midwifery professions require psychosocial support to preserve their health both in the short and long term. Ensuring individualized tailored support will require a layered response within organizations aimed at individual self-care and collegial peer support.

    Patient or Public Contribution

    There was no patient or public contribution in this study, as the focus was on nurses and midwives.

    ☐ ☆ ✇ Journal of Advanced Nursing

    Enhancing knowledge management in nursing through documentation

    Por: Anne Kuusisto · Karen H. Morin — Febrero 10th 2024 at 05:50
    Journal of Advanced Nursing, Volume 80, Issue 3, Page 848-850, March 2024.
    ☐ ☆ ✇ Journal of Advanced Nursing

    A strengths‐based qualitative exploration of critical care nurses' reasons for remaining in critical care

    Abstract

    Aims

    Globally, the nursing shortage is a growing concern. Much of the research on retention of nurses focuses on the experience of those who left positions. In this study, we set out to listen to critical care nurses (CCRNs) who have chosen to remain in their positions to understand the factors retaining them in critical care.

    Design

    This interpretive descriptive study was guided by the following research question: ‘what factors influence CCRN's decision to continue to work in critical care?’

    Methods

    Digitally recorded interviews and a focus group were conducted between July 2022 and January 2023 using a semi-structured, strengths-based interview guide with CCRNs from three critical care units at a tertiary hospital in a city in a central Canadian province. Transcribed interviews were analysed using open, axial and selective coding and constant comparative analysis.

    Results

    Twenty-two CCRNs participated in interviews and three in a focus group. The theme of Respect, demonstrated through the interconnected concepts of Working to Full Scope, Team, Rotations and Compensation was identified. Working to Full Scope was described as providing nursing care aligned with how each nurse envisions what nursing is. Being part of a Team led by strong nurse leaders that provides opportunities and supports the sharing of their perspectives was also found. Respect was also found to be demonstrated through Rotations that recognize that work is one part of these nurses' lives. Compensation that reflects the increased education, knowledge and skills required in critical care was the final concept of Respect.

    Conclusion

    Organizations should focus their efforts across the identified concepts to demonstrate Respect for CCRNs and retain them.

    Implications for Practice

    The findings of this study provide ways to support the retention of CCRNs.

    Impact

    This research will have an impact on nursing leaders by providing tangible ways to retain CCRNs.

    Reporting Method

    Reporting of this work was guided by the Standards for Reporting Qualitative Research.

    Patient or Public Contribution

    No patient or public contribution.

    ☐ ☆ ✇ Journal of Advanced Nursing

    The EMeRGE theory of emerging adult‐aged women's sexual and reproductive health self‐management: A grounded theory study

    Abstract

    Aims

    To explore how emerging adult-aged women self-manage their sexual and reproductive health and to generate a grounded theory of these self-management processes.

    Design

    Grounded theory methods using a constructivist approach.

    Methods

    Between September 2019 and September 2020, 18‑ to 25-years-old women (n = 13) were recruited from a 4-year university, a 2-year community college, and neighbourhoods surrounding the institutions of higher education. Individual interviews were transcribed verbatim and qualitatively analysed using a constant comparative method and inductive coding.

    Results

    The theory purports that core processes of sexual and reproductive health self-management used by the women in this study included both passive and (re)active processes. These processes expanded upon and/or maintained the women's accessible sexual and reproductive health knowledge, behaviour and beliefs, defined as the sexual and reproductive health repertoire. The processes appeared to be cyclical and were often initiated by a catalysing event or catalyst and resulted in conversations with confidantes, or trusted individuals. A catalyst was either resolved or normalized by expanding or maintaining the sexual and reproductive health repertoire.

    Conclusion

    The resulting theory, EMeRGE Theory, offers insight into the complex and cyclical processes emerging adult-aged women use to simultaneously develop and adapt their foundational sexual and reproductive health knowledge, behaviours and beliefs.

    Implications for the Profession and/or Patient Care

    This explication of emerging adult-aged women's sexual and reproductive health self-management processes can be used by nurses and nurse researchers to better address this population's unique health needs.

    Impact

    The EMeRGE Theory provides valuable guidance for future exploratory and intervention research aimed at improving the health and well-being of emerging adult-aged women.

    Reporting Method

    The authors adhered to the Consolidated Criteria for Reporting Qualitative studies (COREQ) in preparation of this publication.

    Patient or Public Contribution

    No patient or public contribution.

    ☐ ☆ ✇ Worldviews on Evidence-Based Nursing

    A systematic review of the facilitators and barriers to rapid response team activation

    Por: Jonathan D. Hecht · Linda H. Yoder · Valerie Danesh · Elizabeth M. Heitkemper — Diciembre 30th 2023 at 15:03

    Abstract

    Background

    Outcomes associated with rapid response teams (RRTs) are inconsistent. This may be due to underlying facilitators and barriers to RRT activation that are affected by team leaders and health systems.

    Aims

    The aim of this study was to synthesize the published research about facilitators and barriers to nurse-led RRT activation in the United States (U.S.).

    Methods

    A systematic review was conducted. Four databases were searched from January 2000 to June 2023 for peer-reviewed quantitative, qualitative, and mixed methods studies reporting facilitators and barriers to RRT activation. Studies conducted outside the U.S. or with physician-led teams were excluded.

    Results

    Twenty-five studies met criteria representing 240,140 participants that included clinicians and hospitalized adults. Three domains of facilitators and barriers to RRT activation were identified: (1) hospital infrastructure, (2) clinician culture, and (3) nurses' beliefs, attributes, and knowledge. Categories were identified within each domain. The categories of perceived benefits and positive beliefs about RRTs, knowing when to activate the RRT, and hospital-wide policies and practices most facilitated activation, whereas the categories of negative perceptions and concerns about RRTs and uncertainties surrounding RRT activation were the dominant barriers.

    Linking Evidence to Action

    Facilitators and barriers to RRT activation were interrelated. Some facilitators like hospital leader and physician support of RRTs became barriers when absent. Intradisciplinary communication and collaboration between nurses can positively and negatively impact RRT activation. The expertise of RRT nurses should be further studied.

    ☐ ☆ ✇ Journal of Clinical Nursing

    Interventions to promote the implementation of pressure injury prevention measures in nursing homes: A scoping review

    Por: L. F. Yang · J. X. Mu · J. Zhang · S. Zang · L. Zhang · J. H. Qi · C. P. Ni · Y. Liu — Diciembre 29th 2023 at 12:34

    Abstract

    Aims

    To identify studies and the content of the interventions that have facilitated the implementation of pressure injury (PI) prevention measures in nursing home settings.

    Design and Method

    A scoping review methodology was employed. The author has carried out the following steps successively: Identified this scoping review's questions, retrieved potentially relevant studies, selected relevant studies, charted the data, summarised the results, and consulted with stakeholders from nursing homes in China.

    Data Sources

    Six electronic databases and three resources of grey literature—PubMed, CINAHL, Web of Science Core Collection, Embase, Cochrane Central Register of Controlled Trials, Psych INFO, Open Grey, MedNar, ProQuest Dissertations, and Theses Full Texts were searched from January 2002 through May 2022.

    Results

    Forty articles were included, among which the primary interventions were quality improvement, training and education, evidence-based practice, device-assisted PI prophylaxis, nursing protocols, and clinical decision support systems. Twenty-three outcome indicators were summarised in 40 articles, which included 10 outcome indicators, seven process indicators, and six structural indicators. Furthermore, only five articles reported barriers in the process of implementing interventions.

    Conclusion

    The common interventions to promote the implementation of PI prevention measures in nursing homes are quality improvement, training, and education. Relatively limited research has been conducted on evidence-based practice, clinical decision support systems, device-assisted PI prophylaxis, and nursing protocols. In addition, there is a paucity of studies examining the impediments to implementing these measures and devising targeted solutions. Therefore, it is recommended that future studies include analysis and reporting of barriers and facilitators as part of the article to improve the sustainability of the intervention.

    Impact

    This article reminds nursing home managers that they should realise the importance of implementation strategies between the best evidence of PI prevention and clinical practice. Also, this review provides the types, contents, and outcome indicators of these strategies for managers of nursing homes to consider what types of interventions to implement in their organisations.

    TRIAL AND PROTOCOL REGISTRATION

    The protocol of this scoping review was published as an open-access article in June 2022 (Yang et al., 2022).

    ☐ ☆ ✇ Journal of Nursing Scholarship

    An examination of retracted articles in nursing literature

    Abstract

    Introduction

    The output of scholarly publications in scientific literature has increased exponentially in recent years. This increase in literature has been accompanied by an increase in retractions. Although some of these may be attributed to publishing errors, many are the result of unsavory research practices. The purposes of this study were to identify the number of retracted articles in nursing and reasons for the retractions, analyze the retraction notices, and determine the length of time for an article in nursing to be retracted.

    Design

    This was an exploratory study.

    Methods

    A search of PubMed/MEDLINE, the Cumulative Index to Nursing and Allied Health Literature, and Retraction Watch databases was conducted to identify retracted articles in nursing and their retraction notices.

    Results

    Between 1997 and 2022, 123 articles published in the nursing literature were retracted. Ten different reasons for retraction were used to categorize these articles with one-third of the retractions (n = 37, 30.1%) not specifying a reason. Sixty-eight percent (n = 77) were retracted because of an actual or a potential ethical concern: duplicate publication, data issues, plagiarism, authorship issues, and copyright.

    Conclusion

    Nurses rely on nursing-specific scholarly literature as evidence for clinical decisions. The findings demonstrated that retractions are increasing within published nursing literature. In addition, it was evident that retraction notices do not prevent previously published work from being cited. This study addressed a gap in knowledge about article retractions specific to nursing.

    ☐ ☆ ✇ Evidence-Based Nursing

    Early rehabilitation of patients in the ICU may reduce long-term healthcare costs

    Por: Al Qadire · M. · Abdelrahman · H. — Diciembre 15th 2023 at 10:25

    Commentary on: Murooka Y, Sasabuchi Y, Takazawa T, Matsui H, Yasunaga H, Saito S. Long-Term Prognosis Following Early Rehabilitation in the ICU: A Retrospective Cohort Study. Crit Care Med. 2023 Mar 29. doi: 10.1097/CCM.0000000000005862. Epub ahead of print.

    Implications for practice and research

  • Rehabilitation programmes if introduced early after admissions to intensive care unit could be beneficial to patients and healthcare systems.

  • Prospective studies are needed to confirm the long-term impacts of early introduction of rehabilitation programmes on healthcare outcomes in terms of, quality of life and physical functions, the optimal timing, duration, and intensity of rehabilitation.

  • Context

    Early rehabilitation is a promising treatment for postintensive care syndrome. Studies have demonstrated the benefits of rehabilitation, such as early exercise and mobilisation, which improve short-term physical and functional outcomes and reduce intensive care unit (ICU) and hospital stay durations for critically ill patients.1...

    ☐ ☆ ✇ Nursing Research

    The Effects of Race, Ethnicity, and Maternal Education on Infant Mortality

    imageBackground The state of New Jersey has a large Black/African American (AA) versus White racial disparity in infant mortality and educational level at childbirth. This disparity, measured by rate ratio, increases with greater maternal education among varied racial–ethnic groups. The nature of this disparity measured by rate differences has not been explored. Objectives Infant birth and mortality data were used to examine whether racial or ethnic disparities in infant mortality increased with greater maternal education, comparing rate differences and rate ratios. Racial and ethnic variations in the association between maternal education and infant mortality were examined. Methods Data were from the New Jersey State Health Assessment Data for all New Jersey births between 2014 and 2018 stratified by race and ethnicity, maternal education, and infant mortality (n = 481,333). R software was used to create a data set and estimate additive and multiplicative interactions, rate differences, and rate ratios for infant mortality by maternal race/ethnicity and educational levels among four racial–ethnic groups. Results Infant mortality was significantly greater for Black/AA and Hispanic mothers than for White mothers. At all educational levels, Black/AA mothers had the highest prevalence of infant mortality compared to other racial or ethnic groups. Rate differences in infant mortality showed a decrease in Black/AA–White differences for mothers with a high school education or less compared to mothers with a college degree. However, rate ratios showed an increase in Black/AA–White ratio with increasing education levels for mothers with high school education or less than mothers with a college degree. Risk ratios comparing infant mortality for Black/AA versus Hispanic or Asian mothers showed more than a twofold greater risk at all education levels for Black/AA infants. Finally, college-educated Black/AA mothers had significantly higher rates of infant mortality than White or Hispanic mothers with a high school education or less. Discussion/Implications Black/AA mothers with a college degree had a higher infant mortality rate than White, Hispanic, or Asian mothers with a high school education or less. Future research should address contextual/systemic contributors to this disparity.
    ☐ ☆ ✇ Nursing Research

    Exploring Cytokine Networks in Resistant Hypertension

    Por: Bolin, Linda P. · Crane, Patricia B. · Gunn, Laura H. — Octubre 26th 2023 at 02:00
    imageBackground Controlling high blood pressure (BP) continues to be a major concern because the associated complications can lead to an increased risk of heart, brain, and kidney disease. Those with hypertension, despite lifestyle and diet modifications and pharmacotherapy, defined as resistant hypertension, are at increased risk for further risk for morbidity and mortality. Understanding inflammation in this population may provide novel avenues for treatment. Objectives This study aimed to examine a broad range of cytokines in adults with cardiovascular disease and identify specific cytokines associated with resistant hypertension. Methods A secondary data analysis was conducted. The parent study included 156 adults with a history of myocardial infarction within the past 3–7 years and with a multiplex plasma analysis yielding a cytokine panel. A network analysis with lasso penalization for sparsity was performed to explore associations between cytokines and BP. Associated network centrality measures by cytokine were produced, and a community graph was extracted. A sensitivity analysis BP was also performed. Results Cytokines with larger node strength measures were sTNFR2 and CX3. The graphical network highlighted six cytokines strongly associated with resistant hypertension. Cytokines IL-29 and CCL3 were found to be negatively associated with resistant hypertension, whereas CXCL12, MMP3, sCD163, and sIL6Rb were positively associated with resistant hypertension. Discussion Understanding the network of associations through exploring oxidative stress and vascular inflammation may provide insight into treatment approaches for resistant hypertension.
    ☐ ☆ ✇ Nursing Research

    In Search of Nursing Science

    Por: Pickler · Rita H. — Octubre 7th 2023 at 02:00
    No abstract available
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