Conectar
by Ruilan Lin, Ru Qin, Yunlong Zhang, Yao Guan, Boheng Wu, Shangyang Li, Shenhong Qu, Yulin Yuan
BackgroundThis study aims to assess the diagnostic value of the Epstein-Barr virus (EBV) BNLF2b antibody(P85-Ab), alone or in combination with VCA-IgA, Rta-IgG, and Zta-IgA antibodies, in the context of nasopharyngeal carcinoma (NPC).
MethodsThe study included 100 NPC patients and 100 healthy controls. Chemiluminescent microparticle immunoassay was utilized to measure P85-Ab levels in the serum samples of both NPC patients and healthy controls. Additionally, the ELISA method was employed to detect serum levels of VCA-IgA, Rta-IgG, and Zta-IgA antibodies. The study analyzed the roles of serum P85-Ab in conjunction with VCA-IgA, Rta-IgG, and Zta-IgA antibodies in the diagnosis of NPC.
ResultsSerum levels of P85-Ab, VCA-IgA, Rta-IgG, and Zta-IgA antibodies in NPC patients were significantly higher than those in the normal control group (P Conclusion
The combined detection of P85-Ab with VCA-IgA, Rta-IgG, and Zta-IgA antibodies demonstrates high diagnostic value for nasopharyngeal carcinoma. Serum P85-Ab may serve as a potential marker for the diagnosis of NPC.
by Aneng Cui, Yongxin Dai, Chao Jia, Quansheng Mao, Kelin Yu, Pengcheng Wu, Mengsheng Zhao
Hard structural planes mainly exist in rock slopes and their creep characteristics largely determine slope stability. Traditional models have some shortcomings in describing the creep characteristics of hard structural planes, such as poor adaptability and unclear physical meaning of parameters. In order to overcome these shortcomings, based on the creep failure mechanism of hard structural planes, an element combination model is adopted in the study. In the instantaneous deformation stage, the plastic deformation proportional coefficient n is introduced based on the strain rebound theory of loading-unloading tests. In the attenuation creep stage, the hardening coefficient C and creep index m are introduced. In the viscoelastic-plastic failure stage, the weakening factor k is introduced. By improving traditional elements, a new piecewise nonlinear constitutive relationship of hard structural planes is established and then the creep equation is obtained with integration method. The adaptability of the established model and the way to solve parameters are analyzed and the correctness of the model is proved theoretically. The data of creep tests of the prefabricated serrated interpenetrated green sandstone structural plane and the concealed non-interpenetrated marble structural plane are further fitted and verified, yielding a fitting result exceeding 0.95, thereby indicating a strong correlation. By optimizing the whole creep process of the hard structural plane in stages and demonstrating the difference in the creep mechanism of the hard structural plane at different depths in a rock mass in the high and low stress fields in the form of piecewise function, the physical meaning of the improved model is clearer. In addition, the improved model allows the higher accuracy of nonlinear characteristics in attenuation creep stage and acceleration creep stage and provides the theoretical basis for the stability analysis of rock slopes.
To review the content, format and effectiveness of shared decision-making interventions for mode of delivery after caesarean section for pregnant women.
Systematic review and meta-analysis.
Six databases (PubMed, Web of science Core Collection, Cochrance Network, Embase, CINAHL, PsycINFO) were searched starting at the time of establishment of the database to May 2023. Following the PRISMAs and use Review Manager 5.3 software for meta-analysis. Two review authors independently assessed the quality of the studies using the risk of bias 2 tool. The protocol was registered in PROSPERO (CRD42023410536).
The search strategy obtained 1675 references. After abstract and full text screening, a total of seven studies were included. Shared decision-making interventions include decision aids and counselling that can help pregnant women analyse the pros and cons of various options and help them make decisions that are consistent with their values. The pooled results showed that shared decision-making intervention alleviated decisional conflicts regarding mode of delivery after caesarean section, but had no effect on knowledge and informed choice.
The results of our review suggest that shared decision-making is an effective intervention to improve the quality of decision-making about the mode of delivery of pregnant women after caesarean section. However, due to the low quality of the evidence, it is recommended that more studies be conducted in the future to improve the quality of the evidence.
This systematic review and meta-analysis provides evidence for the effectiveness of shared decision-making for mode of delivery after cesarean section and may provide a basis for the development of intervention to promote the participation of pregnant women in the decision-making process.
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