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N-Terminal pro C-Type Natriuretic Peptide (NTproCNP) and myocardial function in ageing

by Bryan M. H. Keng, Fei Gao, Ru San Tan, See Hooi Ewe, Louis L. Y. Teo, Bei Qi Xie, George B. B. Goh, Woon-Puay Koh, Angela S. Koh

Ageing-related alterations in cardiovascular structure and function are commonly associated with chronic inflammation. A potential blood-based biomarker indicative of a chronic inflammatory state is N-Terminal Pro C-Type Natriuretic Peptide (NTproCNP). We aim to investigate associations between NTproCNP and ageing-related impairments in cardiovascular function. Community-based participants underwent same-day assessment of cardiovascular function and circulating profiles of plasma NTproCNP. Associations between cardiovascular and biomarker profiles were studied in adjusted models including standard covariates. We studied 93 participants (mean age 73 ± 5.3 years, 36 women), of whom 55 (59%) had impaired myocardial relaxation (ratio of peak velocity flow in early diastole E (m/s) to peak velocity flow in late diastole by atrial contraction A (m/s)